2,4(1H,3H)-Pyrimidinedione, 3-[(2R)-2-amino-2-phenylethyl]-5-(2-fluoro-3-methoxyphenyl)-1-[[2-fluoro -6-(methylsulfonyl)phenyl]methyl]-6-methyl-

Base Information

Chemical Name:2,4(1H,3H)-Pyrimidinedione, 3-[(2R)-2-amino-2-phenylethyl]-5-(2-fluoro-3-methoxyphenyl)-1-[[2-fluoro -6-(methylsulfonyl)phenyl]methyl]-6-methyl-
CAS No.:830346-56-0
Molecular Formula:C28H27F2N3O5S
Molecular Weight:555.602
Hs Code.:

2,4(1H,3H)-Pyrimidinedione,
3-[(2R)-2-amino-2-phenylethyl]-5-(2-fluoro-3-methoxyphenyl)-1-[[2-fluoro
-6-(methylsulfonyl)phenyl]methyl]-6-methyl-

Synonyms:

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2,4(1H,3H)-Pyrimidinedione, 3-[(2R)-2-amino-2-phenylethyl]-5-(2-fluoro-3-methoxyphenyl)-1-[[2-fluoro -6-(methylsulfonyl)phenyl]methyl]-6-methyl-

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MSDS Files:: SDS file from LookChem

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Technology Process of 2,4(1H,3H)-Pyrimidinedione, 3-[(2R)-2-amino-2-phenylethyl]-5-(2-fluoro-3-methoxyphenyl)-1-[[2-fluoro -6-(methylsulfonyl)phenyl]methyl]-6-methyl-

There total 1 articles about 2,4(1H,3H)-Pyrimidinedione, 3-[(2R)-2-amino-2-phenylethyl]-5-(2-fluoro-3-methoxyphenyl)-1-[[2-fluoro -6-(methylsulfonyl)phenyl]methyl]-6-methyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 830346-55-9
3-[2(R)-(tert-butoxycarbonylamino)-2-phenylethyl]-5-(2-fluoro-3-methoxyphenyl)-1-[2-fluoro-6-methylsulfonylbenzyl]-6-methylpyrimidine-2,4(1H,3H)-dione

: 830346-56-0
1-(2-fluoro-6-methanesulfinylbenzyl)-3-[(2R)-amino-2-phenethyl]-5-(2-fluoro-3-methoxyphenyl)-6-methyluracil

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 4h;

Reference yield: 67.0%

: 830346-56-0
1-(2-fluoro-6-methanesulfinylbenzyl)-3-[(2R)-amino-2-phenethyl]-5-(2-fluoro-3-methoxyphenyl)-6-methyluracil

: 5460-29-7
2-(3-bromopropyl)isoindole-1,3-dione

: 3-[2(R)-{phthalimidopropylamino}-2-phenylethyl]-5-(2-fluoro-3-methoxyphenyl)-1-[2-fluoro-6-methylsulfonylbenzyl]-6-methyl-pyrimidine-2,4-(1H,3H)-dione

Guidance literature:: With sodium carbonate; In DMF (N,N-dimethyl-formamide); at 80 ℃; for 4h;

Reference yield: 12.0%

: 830346-56-0
1-(2-fluoro-6-methanesulfinylbenzyl)-3-[(2R)-amino-2-phenethyl]-5-(2-fluoro-3-methoxyphenyl)-6-methyluracil

: 832720-90-8
5,5'-[2,4,8,10-tetraoxaspiro[5.5]undecane-3,9-diylbis(ethane-2,1-diyl)]bis-1H-tetrazole

: 3-[2(R)-{2-[1-(5-tetrazoyl)propyl]-amino}-2-phenylethyl]-5-(2-fluoro-3-methoxyphenyl)-1-[2-fluoro-6-methylsulfonylbenzyl]-6-methyl-pyrimidine-2,4-(1H,3H)-dione

Guidance literature:: 5,5'-[2,4,8,10-tetraoxaspiro[5.5]undecane-3,9-diylbis(ethane-2,1-diyl)]bis-1H-tetrazole; With toluene-4-sulfonic acid; In water; at 80 ℃; for 18h;

1-(2-fluoro-6-methanesulfinylbenzyl)-3-[(2R)-amino-2-phenethyl]-5-(2-fluoro-3-methoxyphenyl)-6-methyluracil; With borane pyridine; triethylamine; In ethanol; water; for 0.25h;