Carbamic acid, (1-hydroxy-2-oxo-3-azetidinyl)-, phenylmethyl ester, (S)-

Base Information Edit

Chemical Name:Carbamic acid, (1-hydroxy-2-oxo-3-azetidinyl)-, phenylmethyl ester, (S)-
CAS No.:83105-75-3
Molecular Formula:C11H12N2O4
Molecular Weight:236.22400
Hs Code.:
Mol file:83105-75-3.mol

Synonyms:3-(Cbz-amino)-N-hydroxy-2-azetidinone;(3S)-3-[[(Phenylmethoxy)carbonyl]amino]-1-hydroxy-2-azetidinone;((S)-1-Hydroxy-2-oxo-azetidin-3-yl)-carbamic acid benzyl ester;

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Carbamic acid, (1-hydroxy-2-oxo-3-azetidinyl)-, phenylmethyl ester, (S)- Edit

Chemical Property:

PSA：78.87000
LogP:0.84160

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of Carbamic acid, (1-hydroxy-2-oxo-3-azetidinyl)-, phenylmethyl ester, (S)-

There total 10 articles about Carbamic acid, (1-hydroxy-2-oxo-3-azetidinyl)-, phenylmethyl ester, (S)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.6%

: 88144-10-9
N-acetoxy-3-(Cbz-amino)-2-azetidinone

: 83105-75-3
(3S)-1-hydroxy-3-[[[(phenylmethyl)oxy]carbonyl]amino]-2-azetidinone

Guidance literature:: With sodium carbonate; In methanol; water; for 0.75h;
DOI:10.1016/S0040-4020(01)92150-7

Reference yield: 35.0%

: 1145-80-8,2768-56-1,6081-61-4
N-benzyloxycarbonyl-L-serine

: 83105-75-3
(3S)-1-hydroxy-3-[[[(phenylmethyl)oxy]carbonyl]amino]-2-azetidinone

Guidance literature:: N-benzyloxycarbonyl-L-serine; With polystyrene resin carrying O-trityl-hydroxylamine linker; N-ethyl-N,N-diisopropylamine; 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride; In 1-methyl-pyrrolidin-2-one; at 20 ℃; for 12h;

With triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; at 20 ℃; for 24h;

With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 1h; Further stages.;
DOI:10.1021/ol006779z