4-(Difluoromethoxy)-3-methylaniline

Base Information

Chemical Name:4-(Difluoromethoxy)-3-methylaniline
CAS No.:83190-02-7
Molecular Formula:C8H9F2NO
Molecular Weight:173.162
Hs Code.:
European Community (EC) Number:816-456-6
DSSTox Substance ID:DTXSID10535353
Wikidata:Q82409636

Synonyms:4-(Difluoromethoxy)-3-methylaniline;83190-02-7;4-Difluoromethoxy-3-methylaniline;Benzenamine, 4-(difluoromethoxy)-3-methyl-;SCHEMBL1470373;3-methyl-4-difluoromethoxyaniline;DTXSID10535353;AKOS027270587;AT12928;4-amino-1-difluoromethoxy-2-methyl-benzene;EN300-765672;A1-06510;Z1262644248

Suppliers and Price of 4-(Difluoromethoxy)-3-methylaniline

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 6 raw suppliers

Chemical Property of 4-(Difluoromethoxy)-3-methylaniline

Chemical Property:

XLogP3:2.5
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:2
Exact Mass:173.06522023
Heavy Atom Count:12
Complexity:143

Purity/Quality:: 85.0-99.8% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC1=C(C=CC(=C1)N)OC(F)F

Technology Process of 4-(Difluoromethoxy)-3-methylaniline

There total 3 articles about 4-(Difluoromethoxy)-3-methylaniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 83190-00-5
1-difluoromethoxy-2-methyl-4-nitrobenzene

: 83190-02-7
4-amino-1-difluoromethoxy-2-methyl-benzene

Guidance literature:: With iron; acetic acid; In ethanol; water; for 0.333333h; Heating / reflux;

Reference yield:

: 99-53-6
2-methyl-4-nitrophenol

: 83190-02-7
4-amino-1-difluoromethoxy-2-methyl-benzene

Guidance literature:: Multi-step reaction with 2 steps

1: caesium carbonate / N,N-dimethyl-formamide / 3.33 h / 20 - 100 °C

2: iron; acetic acid / ethanol; water / 0.33 h / Heating / reflux

With iron; caesium carbonate; acetic acid; In ethanol; water; N,N-dimethyl-formamide;