Piperazine, 1-[(5-aminobenzo[b]thien-2-yl)carbonyl]-4-phenyl-

Base Information

Chemical Name:Piperazine, 1-[(5-aminobenzo[b]thien-2-yl)carbonyl]-4-phenyl-
CAS No.:832102-99-5
Molecular Formula:C19H19N3OS
Molecular Weight:337.445
Hs Code.:
DSSTox Substance ID:DTXSID20475458

Synonyms:832102-99-5;Piperazine, 1-[(5-aminobenzo[b]thien-2-yl)carbonyl]-4-phenyl-;SCHEMBL6253982;DTXSID20475458;FT-0766591

Suppliers and Price of Piperazine, 1-[(5-aminobenzo[b]thien-2-yl)carbonyl]-4-phenyl-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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price

Total 1 raw suppliers

Chemical Property of Piperazine, 1-[(5-aminobenzo[b]thien-2-yl)carbonyl]-4-phenyl-

Chemical Property:

XLogP3:3.6
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:2
Exact Mass:337.12488341
Heavy Atom Count:24
Complexity:446

Purity/Quality:: 85.0-99.8% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1CN(CCN1C2=CC=CC=C2)C(=O)C3=CC4=C(S3)C=CC(=C4)N

Technology Process of Piperazine, 1-[(5-aminobenzo[b]thien-2-yl)carbonyl]-4-phenyl-

There total 5 articles about Piperazine, 1-[(5-aminobenzo[b]thien-2-yl)carbonyl]-4-phenyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 361167-81-9
1-[(5-nitro-1-benzothien-2-yl)carbonyl]-4-phenylpiperazine

: 832102-99-5
{2-[(4-phenyl-1-piperazinyl)carbonyl]-1-benzothien-5-yl}amine

Guidance literature:: With hydrogen; Pd/C; In methanol; at 20 ℃; for 4h; under 2068.59 Torr;
DOI:10.1021/jm060814b

Reference yield:

: 20699-86-9
methyl 5-nitrobenzo[b]thiophene-2-carboxylate

: 832102-99-5
{2-[(4-phenyl-1-piperazinyl)carbonyl]-1-benzothien-5-yl}amine

Guidance literature:: Multi-step reaction with 3 steps

1: lithium hydroxide / tetrahydrofuran / 16 h / 20 °C

2: benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; N-ethyl-N,N-diisopropylamine / dichloromethane / 16 h / 20 °C

3: hydrogen / Pd/C / methanol / 4 h / 20 °C / 2068.59 Torr

With lithium hydroxide; hydrogen; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; N-ethyl-N,N-diisopropylamine; Pd/C; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1021/jm060814b

Reference yield:

: 6345-55-7
5-nitrobenzo[b]thiophene-2-carboxylic acid

: 832102-99-5
{2-[(4-phenyl-1-piperazinyl)carbonyl]-1-benzothien-5-yl}amine

Guidance literature:: Multi-step reaction with 2 steps

1: benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; N-ethyl-N,N-diisopropylamine / dichloromethane / 16 h / 20 °C

2: hydrogen / Pd/C / methanol / 4 h / 20 °C / 2068.59 Torr

With hydrogen; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; N-ethyl-N,N-diisopropylamine; Pd/C; In methanol; dichloromethane;
DOI:10.1021/jm060814b