2H,6H-Pyrido[2,1-b][1,3]thiazine-4,9-dicarboxylic acid, 7-[(chloroacetyl)amino]-7,8-dihydro-3-methyl-6-oxo-, 4-methyl 9-(phenylmethyl) ester

Base Information

Chemical Name:2H,6H-Pyrido[2,1-b][1,3]thiazine-4,9-dicarboxylic acid, 7-[(chloroacetyl)amino]-7,8-dihydro-3-methyl-6-oxo-, 4-methyl 9-(phenylmethyl) ester
CAS No.:832111-37-2
Molecular Formula:C21H21ClN2O6S
Molecular Weight:464.927
Hs Code.:

2H,6H-Pyrido[2,1-b][1,3]thiazine-4,9-dicarboxylic acid,
7-[(chloroacetyl)amino]-7,8-dihydro-3-methyl-6-oxo-, 4-methyl
9-(phenylmethyl) ester

Synonyms:

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Chemical Property of 2H,6H-Pyrido[2,1-b][1,3]thiazine-4,9-dicarboxylic acid, 7-[(chloroacetyl)amino]-7,8-dihydro-3-methyl-6-oxo-, 4-methyl 9-(phenylmethyl) ester

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MSDS Files:: SDS file from LookChem

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Technology Process of 2H,6H-Pyrido[2,1-b][1,3]thiazine-4,9-dicarboxylic acid, 7-[(chloroacetyl)amino]-7,8-dihydro-3-methyl-6-oxo-, 4-methyl 9-(phenylmethyl) ester

There total 2 articles about 2H,6H-Pyrido[2,1-b][1,3]thiazine-4,9-dicarboxylic acid, 7-[(chloroacetyl)amino]-7,8-dihydro-3-methyl-6-oxo-, 4-methyl 9-(phenylmethyl) ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: 7560-99-8
2-chloroacetylaminoacrylic acid

: methyl 2-benzyloxycarbonylmethylene-3,6-dihydro-5-methyl-2H-[1,3]-thiazine-4-carboxylate

: 832111-37-2
9-benzyl 4-methyl (7RS)-7-(2-chloroacetylamino)-7,8-dihydro-3-methyl-6-oxo-2H,6H-pyrido[2,1-b][1,3]thiazine-4,9-dicarboxylate

Guidance literature:: With phosphorus trichloride; In 1,4-dioxane; benzene; for 1.5h; Heating;
DOI:10.1016/j.tet.2004.09.036

Reference yield:

: 2-(chloroacetylamino)-acrylic acid

: methyl 2-benzyloxycarbonylmethylene-3,6-dihydro-5-methyl-2H-[1,3]-thiazine-4-carboxylate

: 832111-37-2
9-benzyl 4-methyl (7RS)-7-(2-chloroacetylamino)-7,8-dihydro-3-methyl-6-oxo-2H,6H-pyrido[2,1-b][1,3]thiazine-4,9-dicarboxylate

Guidance literature:: With phosphorus trichloride;
DOI:10.1016/S0040-4039(02)02141-X

Reference yield: 51.0%

: 832111-37-2
9-benzyl 4-methyl (7RS)-7-(2-chloroacetylamino)-7,8-dihydro-3-methyl-6-oxo-2H,6H-pyrido[2,1-b][1,3]thiazine-4,9-dicarboxylate

: 9-benzyl 4-methyl (7RS)-7-amino-7,8-dihydro-3-methyl-6-oxo-2H,6H-pyrido[2,1-b][1,3]thiazine-4,9-dicarboxylate

Guidance literature:: With lithium hydroxide; o-phenylenediamine dihydrochloride; In ethanol; water; at 100 ℃; for 48h;
DOI:10.1016/j.tet.2004.09.036