Pyridine, 2-chloro-6-[3-[(1R)-1-methoxy-1-phenylethyl]-5-methyl-1H-pyrazol-1-yl]-

Base Information

Chemical Name:Pyridine, 2-chloro-6-[3-[(1R)-1-methoxy-1-phenylethyl]-5-methyl-1H-pyrazol-1-yl]-
CAS No.:832688-55-8
Molecular Formula:C18H18ClN3O
Molecular Weight:327.813
Hs Code.:

Synonyms:

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Chemical Property of Pyridine, 2-chloro-6-[3-[(1R)-1-methoxy-1-phenylethyl]-5-methyl-1H-pyrazol-1-yl]-

Chemical Property:

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MSDS Files:: SDS file from LookChem

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Technology Process of Pyridine, 2-chloro-6-[3-[(1R)-1-methoxy-1-phenylethyl]-5-methyl-1H-pyrazol-1-yl]-

There total 6 articles about Pyridine, 2-chloro-6-[3-[(1R)-1-methoxy-1-phenylethyl]-5-methyl-1H-pyrazol-1-yl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

: 2402-78-0
2,6-dichloropyridine

: 832688-52-5
(R)-3⁽⁵⁾-(1-methoxy-1-phenyl-ethyl)-5⁽³⁾-methyl-1H-pyrazole

: 832688-55-8
(R)-2-chloro-6-[3-(1-methoxy-1-phenylethyl)-5-methylpyrazol-1-yl]pyridine

Guidance literature:: (R)-3⁽⁵⁾-(1-methoxy-1-phenyl-ethyl)-5⁽³⁾-methyl-1H-pyrazole; With ethanol; potassium; In toluene; at 90 ℃;

2,6-dichloropyridine; In N,N-dimethyl-formamide; toluene; at 67 ℃; for 120h;
DOI:10.1016/j.tet.2004.10.092

Reference yield:

: 4358-87-6
(RS)-methyl mandelate

: 832688-55-8
(R)-2-chloro-6-[3-(1-methoxy-1-phenylethyl)-5-methylpyrazol-1-yl]pyridine

Guidance literature:: Multi-step reaction with 8 steps

1.1: K₂CO₃; Adogen / toluene / 20 - 90 °C

2.1: LDA / tetrahydrofuran / -60 - 0 °C

2.2: tetrahydrofuran / 18 h / -60 - 20 °C

3.1: aq. NaOH / ethanol

3.2: 28.7 g / aq. HCl

4.1: Brucine / acetone

4.2: aq. HCl

5.1: 84 percent / DOWEX X₅₀-H(+) / methanol / 10 h / Heating

6.1: sodium hydride / diethyl ether / 1.5 h / 25 °C

6.2: 78 percent Chromat_. / diethyl ether / 1.58 h

7.1: 60 percent / hydrazine monohydrate / ethanol / 0.5 h / Heating

8.1: potassium; EtOH / toluene / 90 °C

8.2: 62 percent / dimethylformamide; toluene / 120 h / 67 °C

With sodium hydroxide; ethanol; DOWEX X₅₀-H(+); triisooctyl amine; potassium; sodium hydride; potassium carbonate; hydrazine hydrate; brucine; lithium diisopropyl amide; In tetrahydrofuran; methanol; diethyl ether; ethanol; acetone; toluene;
DOI:10.1016/j.tet.2004.10.092

Reference yield:

: 7472-67-5
α-phenyl-α-methoxypropanoic acid

: 832688-55-8
(R)-2-chloro-6-[3-(1-methoxy-1-phenylethyl)-5-methylpyrazol-1-yl]pyridine

Guidance literature:: Multi-step reaction with 5 steps

1.1: Brucine / acetone

1.2: aq. HCl

2.1: 84 percent / DOWEX X₅₀-H(+) / methanol / 10 h / Heating

3.1: sodium hydride / diethyl ether / 1.5 h / 25 °C

3.2: 78 percent Chromat_. / diethyl ether / 1.58 h

4.1: 60 percent / hydrazine monohydrate / ethanol / 0.5 h / Heating

5.1: potassium; EtOH / toluene / 90 °C

5.2: 62 percent / dimethylformamide; toluene / 120 h / 67 °C

With ethanol; DOWEX X₅₀-H(+); potassium; sodium hydride; hydrazine hydrate; brucine; In methanol; diethyl ether; ethanol; acetone; toluene;
DOI:10.1016/j.tet.2004.10.092