N-(4-METHYLPHENYL)-1H-BENZIMIDAZOL-2-AMINE

Base Information

• Chemical Name: N-(4-METHYLPHENYL)-1H-BENZIMIDAZOL-2-AMINE
• CAS No.: 83318-15-4
• Molecular Formula: C14H13N3
• Molecular Weight: 223.277
• Mol file: 83318-15-4.mol

Synonyms:(1H-benzimidazol-2-yl)-p-tolyl-amine;N-(p-polyl)-1H-benzo[d]imidazol-2-amine;N-(p-tolyl)-1H-benzo[d]imidazol-2-amine;(1H-Benzoimidazol-2-yl)-p-tolyl-amine;(1H-Benzimidazol-2-yl)-p-tolyl-amin;

Chemical Property of N-(4-METHYLPHENYL)-1H-BENZIMIDAZOL-2-AMINE

Chemical Property:

• Melting Point: 120 - 122 °C
• PSA: 40.71000
• LogP: 3.68790

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

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Technology Process of N-(4-METHYLPHENYL)-1H-BENZIMIDAZOL-2-AMINE

There total 12 articles about N-(4-METHYLPHENYL)-1H-BENZIMIDAZOL-2-AMINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

N-(2-amino-phenyl)-N'-p-tolyl-thiourea (412309-12-7) → N-(4-methylphenyl)-1H-benzo[d]imidazol-2-amine (83318-15-4)

Guidance literature:

With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; 1,8-diazabicyclo[5.4.0]undec-7-ene; In acetonitrile; at 20 ℃;

DOI:10.1016/j.tetlet.2011.05.146

Reference yield: 84.0%

1H-benzimidazol-2-amine (934-32-7) + 4-methylphenylboronic acid (5720-05-8) → N-(4-methylphenyl)-1H-benzo[d]imidazol-2-amine (83318-15-4)

Guidance literature:

With nickel diacetate; 1,8-diazabicyclo[5.4.0]undec-7-ene; In dimethyl sulfoxide; at 50 ℃; for 10h; chemoselective reaction;

DOI:10.1039/c6ob01307d

Reference yield: 81.0%

di-p-tolylcarbodiimide (726-42-1) + 1,2-diamino-benzene (95-54-5) → C14H13N3 (83318-15-4)

Guidance literature:

With [?:η1:η5-(OCH2)(Me2NCH2)C2B9H9]Ti-(NMe2); In toluene; at 115 ℃; for 36h;

DOI:10.1021/ol201752e

upstream raw materials:

di-p-tolylcarbodiimide

1,2-diamino-benzene

methyl (N-(4-methylphenyl))dithiocarbamate

dimethyl N-(4-methylphenyl)dithioimidocarbonate

Downstream raw materials:

C₂₀H₁₅N₅OS

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