5-Pyrimidinamine, 4-chloro-6-[(3,4-dimethoxyphenyl)thio]-

Base Information

Chemical Name:5-Pyrimidinamine, 4-chloro-6-[(3,4-dimethoxyphenyl)thio]-
CAS No.:833451-75-5
Molecular Formula:C₁₂H₁₂ClN₃O₂S
Molecular Weight:297.765
Hs Code.:
DSSTox Substance ID:DTXSID60470649
Wikidata:Q82298805

Synonyms:833451-75-5;4-Chloro-6-((3,4-dimethoxyphenyl)thio)pyrimidin-5-amine;5-Pyrimidinamine, 4-chloro-6-[(3,4-dimethoxyphenyl)thio]-;SCHEMBL6234362;DTXSID60470649

Suppliers and Price of 5-Pyrimidinamine, 4-chloro-6-[(3,4-dimethoxyphenyl)thio]-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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price

Total 1 raw suppliers

Chemical Property of 5-Pyrimidinamine, 4-chloro-6-[(3,4-dimethoxyphenyl)thio]-

Chemical Property:

XLogP3:2.8
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:4
Exact Mass:297.0338755
Heavy Atom Count:19
Complexity:288

Purity/Quality:: 85.0-99.8% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:COC1=C(C=C(C=C1)SC2=C(C(=NC=N2)Cl)N)OC

Technology Process of 5-Pyrimidinamine, 4-chloro-6-[(3,4-dimethoxyphenyl)thio]-

There total 1 articles about 5-Pyrimidinamine, 4-chloro-6-[(3,4-dimethoxyphenyl)thio]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 24.0%

: 5413-85-4
5-amino-4,6-dichloropyridimine

: 700-96-9
3,4-dimethoxythiophenol

: 833451-75-5
4-chloro-6-(3,4-dimethoxy-phenylsulfanyl)-pyrimidin-5-ylamine

Guidance literature:: With potassium carbonate; In ethanol; for 6h; Heating;
DOI:10.1021/jo051419g

Reference yield:

: 833451-75-5
4-chloro-6-(3,4-dimethoxy-phenylsulfanyl)-pyrimidin-5-ylamine

: 1-(3-chloro-2-fluoro-phenoxy)-7,8-dimethoxy-10,11-dihydro-5-thia-2,4,11-triazadibenzo[a,d]cycloheptene

Guidance literature:: Multi-step reaction with 2 steps

1: trifluoroacetic acid; MgSO₄ / dimethylsulfoxide / 40 °C

2: K₂CO₃ / dimethylformamide / 65 - 80 °C

With magnesium sulfate; potassium carbonate; trifluoroacetic acid; In dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2006.07.031

Reference yield:

: 833451-75-5
4-chloro-6-(3,4-dimethoxy-phenylsulfanyl)-pyrimidin-5-ylamine

: 1-(3-bromo-phenoxy)-7,8-dimethoxy-10,11-dihydro-5-thia-2,4,11-triazadibenzo[a,d]cycloheptene

Guidance literature:: Multi-step reaction with 2 steps

1: trifluoroacetic acid; MgSO₄ / dimethylsulfoxide / 40 °C

2: K₂CO₃ / dimethylformamide / 65 - 80 °C

With magnesium sulfate; potassium carbonate; trifluoroacetic acid; In dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2006.07.031