4,8-Methanopyrazolo[3,4-d]azepine, 1-(4-fluorophenyl)-1,4,5,6,7,8-hexahydro-

Base Information

Chemical Name:4,8-Methanopyrazolo[3,4-d]azepine, 1-(4-fluorophenyl)-1,4,5,6,7,8-hexahydro-
CAS No.:833459-00-0
Molecular Formula:C₁₄H₁₄FN₃
Molecular Weight:243.284
Hs Code.:

Synonyms:

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Chemical Property of 4,8-Methanopyrazolo[3,4-d]azepine, 1-(4-fluorophenyl)-1,4,5,6,7,8-hexahydro-

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Technology Process of 4,8-Methanopyrazolo[3,4-d]azepine, 1-(4-fluorophenyl)-1,4,5,6,7,8-hexahydro-

There total 10 articles about 4,8-Methanopyrazolo[3,4-d]azepine, 1-(4-fluorophenyl)-1,4,5,6,7,8-hexahydro- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 833459-01-1
9-benzyl-3-(4-fluoro-phenyl)-3,4,9-triaza-tricyclo[5.3.1.02,6]undeca-2(6),4-dien, HCl salt

: 833459-00-0,833459-27-1,833459-44-2
3-(4-fluoro-phenyl)-3,4,9-triaza-tricyclo[5.3.1.02,6]undeca-2⁽⁶⁾,4-diene

Guidance literature:: With piperidine; formic acid; 10% Pd(OH)2/C; In methanol; for 18h; Heating / reflux;

Reference yield:

: 3-benzyl-3-aza-bicyclo[3.2.1]octan-6-ol

: 833459-00-0,833459-27-1,833459-44-2
3-(4-fluoro-phenyl)-3,4,9-triaza-tricyclo[5.3.1.02,6]undeca-2⁽⁶⁾,4-diene

Guidance literature:: Multi-step reaction with 5 steps

1: tetrapropylammonium perruthennate; 4-methylmorpholine N-oxide / dichloromethane / 1.5 h / 0 - 20 °C

2: 8 h / 100 °C

3: ethanol / Heating / reflux

4: hydrogenchloride / methanol; diethyl ether / 0.75 h

5: piperidine; formic acid / 10% Pd(OH)2/C / methanol / 18 h / Heating / reflux

With piperidine; hydrogenchloride; formic acid; tetrapropylammonium perruthennate; 4-methylmorpholine N-oxide; 10% Pd(OH)2/C; In methanol; diethyl ether; ethanol; dichloromethane;

Reference yield:

: 1375065-49-8
acetic acid 2,4-diformyl-cyclopentyl ester

: 833459-00-0,833459-27-1,833459-44-2
3-(4-fluoro-phenyl)-3,4,9-triaza-tricyclo[5.3.1.02,6]undeca-2⁽⁶⁾,4-diene

Guidance literature:: Multi-step reaction with 7 steps

1.1: acetic acid / dichloromethane; water / 2 h / 20 °C

1.2: 18 h / 20 °C

2.1: potassium hydroxide; water / methanol / 18 h / 20 °C

3.1: tetrapropylammonium perruthennate; 4-methylmorpholine N-oxide / dichloromethane / 1.5 h / 0 - 20 °C

4.1: 8 h / 100 °C

5.1: ethanol / Heating / reflux

6.1: hydrogenchloride / methanol; diethyl ether / 0.75 h

7.1: piperidine; formic acid / 10% Pd(OH)2/C / methanol / 18 h / Heating / reflux

With piperidine; hydrogenchloride; potassium hydroxide; formic acid; tetrapropylammonium perruthennate; water; acetic acid; 4-methylmorpholine N-oxide; 10% Pd(OH)2/C; In methanol; diethyl ether; ethanol; dichloromethane; water;