Benzoic acid, 4-[(2Z,4R)-4-carboxy-1-[[(phenylmethoxy)carbonyl]amino]-2-(trimethylsil yl)-2-pentenyl]-, 1-methyl ester

Base Information

Chemical Name:Benzoic acid, 4-[(2Z,4R)-4-carboxy-1-[[(phenylmethoxy)carbonyl]amino]-2-(trimethylsil yl)-2-pentenyl]-, 1-methyl ester
CAS No.:833487-69-7
Molecular Formula:C25H31NO6Si
Molecular Weight:469.61
Hs Code.:

Synonyms:4-((Z)-(R)-1-Benzyloxycarbonylamino-4-carboxy-2-trimethylsilanyl-pent-2-enyl)-benzoic acid methyl ester;

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Benzoic acid, 4-[(2Z,4R)-4-carboxy-1-[[(phenylmethoxy)carbonyl]amino]-2-(trimethylsil yl)-2-pentenyl]-, 1-methyl ester

Chemical Property:

PSA：101.93000
LogP:5.35610

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of Benzoic acid, 4-[(2Z,4R)-4-carboxy-1-[[(phenylmethoxy)carbonyl]amino]-2-(trimethylsil yl)-2-pentenyl]-, 1-methyl ester

There total 5 articles about Benzoic acid, 4-[(2Z,4R)-4-carboxy-1-[[(phenylmethoxy)carbonyl]amino]-2-(trimethylsil yl)-2-pentenyl]-, 1-methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 833487-68-6
4-[(1SR,2Z,4R)-1-benzyloxycarbonylamino-4-methyl-5-oxo-2-trimethylsilanylpent-2-enyl]benzoic acid methyl ester

: 833487-69-7
4-[(1SR,2Z,4R)-1-benzyloxycarbonylamino-4-carboxy-2-trimethylsilanylpent-2-enyl]benzoic acid methyl ester

Guidance literature:: With sodium chlorite; sodium dihydrogenphosphate; 2-methyl-but-2-ene; In tetrahydrofuran; water; at 0 ℃; for 2h;
DOI:10.1021/ol0477529

Reference yield:

: 833487-59-5
4-[(1SR,2Z,4R)-1-benzyloxycarbonylamino-5-hydroxy-4-methyl-2-trimethylsilanylpent-2-enyl]benzoic acid methyl ester

: 833487-69-7
4-[(1SR,2Z,4R)-1-benzyloxycarbonylamino-4-carboxy-2-trimethylsilanylpent-2-enyl]benzoic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 79 percent / Dess-Martin periodinane / CH₂Cl₂ / 2 h / 0 °C

2: 99 percent / NaClO₂; 2-methyl-2-butene; NaH₂PO₄*H₂O / tetrahydrofuran; H₂O / 2 h / 0 °C

With sodium chlorite; sodium dihydrogenphosphate; 2-methyl-but-2-ene; Dess-Martin periodane; In tetrahydrofuran; dichloromethane; water;
DOI:10.1021/ol0477529

Reference yield:

: 833487-58-4
C₄₅H₅₄NO₄PSi₂

: 833487-69-7
4-[(1SR,2Z,4R)-1-benzyloxycarbonylamino-4-carboxy-2-trimethylsilanylpent-2-enyl]benzoic acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: hydrogen chloride / methanol / 10 h / 20 °C

1.2: 50 percent / NaHCO₃ / CH₂Cl₂ / 20 °C

2.1: 79 percent / Dess-Martin periodinane / CH₂Cl₂ / 2 h / 0 °C

3.1: 99 percent / NaClO₂; 2-methyl-2-butene; NaH₂PO₄*H₂O / tetrahydrofuran; H₂O / 2 h / 0 °C

With hydrogenchloride; sodium chlorite; sodium dihydrogenphosphate; 2-methyl-but-2-ene; Dess-Martin periodane; In tetrahydrofuran; methanol; dichloromethane; water;
DOI:10.1021/ol0477529