Benzenebutanoic acid, a-oxo-, 1-methylethyl ester

Base Information

• Chemical Name: Benzenebutanoic acid, a-oxo-, 1-methylethyl ester
• CAS No.: 83402-89-5
• Molecular Formula: C13H16O3
• Molecular Weight: 220.268
• Mol file: 83402-89-5.mol

Synonyms:

Chemical Property of Benzenebutanoic acid, a-oxo-, 1-methylethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Benzenebutanoic acid, a-oxo-, 1-methylethyl ester

There total 10 articles about Benzenebutanoic acid, a-oxo-, 1-methylethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

C17H20O3 (1289115-91-8) → 2-oxo-4-phenyl-butyric acid isopropyl ester (83402-89-5)

Guidance literature:

With water; copper(II) bis(trifluoromethanesulfonate); toluene-4-sulfonic acid; In dichloromethane; at 20 ℃; for 25h;

DOI:10.1021/ol200558j

Reference yield:

C9H14O3 (1289116-44-4) → 2-oxo-4-phenyl-butyric acid isopropyl ester (83402-89-5)

Guidance literature:

Multi-step reaction with 4 steps

1.1: lithium diisopropyl amide / tetrahydrofuran; hexane / 0.25 h / -78 °C

1.2: 1.5 h / -78 °C

2.1: triethylamine / dichloromethane / 1 h / 0 - 20 °C

3.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / tetrahydrofuran / 19 h / 0 - 20 °C

4.1: water; copper(II) bis(trifluoromethanesulfonate); toluene-4-sulfonic acid / dichloromethane / 25 h / 20 °C

With water; copper(II) bis(trifluoromethanesulfonate); toluene-4-sulfonic acid; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; lithium diisopropyl amide; In tetrahydrofuran; hexane; dichloromethane; 1.1: Aldol condensation / 1.2: Aldol condensation;

DOI:10.1021/ol200558j

Reference yield:

C17H22O4 (1289116-30-8) → 2-oxo-4-phenyl-butyric acid isopropyl ester (83402-89-5)

Guidance literature:

Multi-step reaction with 3 steps

1: triethylamine / dichloromethane / 1 h / 0 - 20 °C

2: 1,8-diazabicyclo[5.4.0]undec-7-ene / tetrahydrofuran / 19 h / 0 - 20 °C

3: water; copper(II) bis(trifluoromethanesulfonate); toluene-4-sulfonic acid / dichloromethane / 25 h / 20 °C

With water; copper(II) bis(trifluoromethanesulfonate); toluene-4-sulfonic acid; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; In tetrahydrofuran; dichloromethane;

DOI:10.1021/ol200558j

upstream raw materials:

2-oxo-4-phenylbutyric acid methyl ester

isopropyl alcohol

2-oxo-4-phenylbutanoic acid ethyl ester

C₁₇H₂₂O₄