Benzenebutanoic acid, 4-methyl-a-oxo-, ethyl ester

Base Information

• Chemical Name: Benzenebutanoic acid, 4-methyl-a-oxo-, ethyl ester
• CAS No.: 83402-93-1
• Molecular Formula: C13H16O3
• Molecular Weight: 220.268
• Mol file: 83402-93-1.mol

Synonyms:

Chemical Property of Benzenebutanoic acid, 4-methyl-a-oxo-, ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Benzenebutanoic acid, 4-methyl-a-oxo-, ethyl ester

There total 3 articles about Benzenebutanoic acid, 4-methyl-a-oxo-, ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

2-Hydroxy-4-p-tolyl-butyric acid ethyl ester → ethyl 4-(p-methylphenyl)-2-oxobutyrate (83402-93-1)

Guidance literature:

With 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; calcium methylate; In acetonitrile; at 0 - 20 ℃;

DOI:10.1080/00397911.2011.584650

Reference yield:

2-(4-methylphenyl)ethyl bromide (6529-51-7) + oxalic acid diethyl ester (95-92-1) → ethyl 4-(p-methylphenyl)-2-oxobutyrate (83402-93-1)

Guidance literature:

2-(4-methylphenyl)ethyl bromide; With magnesium; In tetrahydrofuran; for 1h; Reflux; Inert atmosphere;

oxalic acid diethyl ester; In tetrahydrofuran; at -10 ℃; for 1.5h; Inert atmosphere;

With hydrogenchloride; In tetrahydrofuran; water; Inert atmosphere;

DOI:10.1016/j.tet.2011.06.071

Reference yield:

oxalic acid diethyl ester (95-92-1) + C9H11BrMg → ethyl 4-(p-methylphenyl)-2-oxobutyrate (83402-93-1)

Guidance literature:

In diethyl ether; Yield given; Ambient temperature;

DOI:10.1016/S0957-4166(98)00277-8

upstream raw materials:

oxalic acid diethyl ester

2-(4-methylphenyl)ethyl bromide

Downstream raw materials:

4-(p-methylphenyl)-2-oxobutanoic acid

C₁₁H₁₄O₃