1,3-Dioxane-4-methanol, 6-[(1S,6R)-6-[[[(1,1-dimethylethyl)dimethylsilyl]oxy]methyl]-6-[(2S,3R)-2, 3-dimethyl-4-[[tris(1-methylethyl)silyl]oxy]butyl]-3-[(methoxymethoxy)meth yl]-2-cyclohexen-1-yl]-5-hydroxy-2,2-dimethyl-, (4R,5S,6S)-

Base Information

Chemical Name:1,3-Dioxane-4-methanol, 6-[(1S,6R)-6-[[[(1,1-dimethylethyl)dimethylsilyl]oxy]methyl]-6-[(2S,3R)-2, 3-dimethyl-4-[[tris(1-methylethyl)silyl]oxy]butyl]-3-[(methoxymethoxy)meth yl]-2-cyclohexen-1-yl]-5-hydroxy-2,2-dimethyl-, (4R,5S,6S)-
CAS No.:834916-86-8
Molecular Formula:C38H76O8Si2
Molecular Weight:717.188
Hs Code.:

1,3-Dioxane-4-methanol,
6-[(1S,6R)-6-[[[(1,1-dimethylethyl)dimethylsilyl]oxy]methyl]-6-[(2S,3R)-2,
3-dimethyl-4-[[tris(1-methylethyl)silyl]oxy]butyl]-3-[(methoxymethoxy)meth
yl]-2-cyclohexen-1-yl]-5-hydroxy-2,2-dimethyl-, (4R,5S,6S)-

Synonyms:

Suppliers and Price of 1,3-Dioxane-4-methanol, 6-[(1S,6R)-6-[[[(1,1-dimethylethyl)dimethylsilyl]oxy]methyl]-6-[(2S,3R)-2, 3-dimethyl-4-[[tris(1-methylethyl)silyl]oxy]butyl]-3-[(methoxymethoxy)meth yl]-2-cyclohexen-1-yl]-5-hydroxy-2,2-dimethyl-, (4R,5S,6S)-

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Chemical Property of 1,3-Dioxane-4-methanol, 6-[(1S,6R)-6-[[[(1,1-dimethylethyl)dimethylsilyl]oxy]methyl]-6-[(2S,3R)-2, 3-dimethyl-4-[[tris(1-methylethyl)silyl]oxy]butyl]-3-[(methoxymethoxy)meth yl]-2-cyclohexen-1-yl]-5-hydroxy-2,2-dimethyl-, (4R,5S,6S)-

Chemical Property:

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Hazard Codes:

MSDS Files:: SDS file from LookChem

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Technology Process of 1,3-Dioxane-4-methanol, 6-[(1S,6R)-6-[[[(1,1-dimethylethyl)dimethylsilyl]oxy]methyl]-6-[(2S,3R)-2, 3-dimethyl-4-[[tris(1-methylethyl)silyl]oxy]butyl]-3-[(methoxymethoxy)meth yl]-2-cyclohexen-1-yl]-5-hydroxy-2,2-dimethyl-, (4R,5S,6S)-

There total 5 articles about 1,3-Dioxane-4-methanol, 6-[(1S,6R)-6-[[[(1,1-dimethylethyl)dimethylsilyl]oxy]methyl]-6-[(2S,3R)-2, 3-dimethyl-4-[[tris(1-methylethyl)silyl]oxy]butyl]-3-[(methoxymethoxy)meth yl]-2-cyclohexen-1-yl]-5-hydroxy-2,2-dimethyl-, (4R,5S,6S)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 834916-85-7
(4S,4aS,6R,8aR)-4-[(1S,6R)-6-(tert-Butyl-dimethyl-silanyloxymethyl)-6-((2S,3R)-2,3-dimethyl-4-triisopropylsilanyloxy-butyl)-3-methoxymethoxymethyl-cyclohex-2-enyl]-2,2-dimethyl-6-phenyl-tetrahydro-[1,3]dioxino[5,4-d][1,3]dioxine

: 834916-86-8
(4S,5S,6R)-4-[(1S,6R)-6-(tert-Butyl-dimethyl-silanyloxymethyl)-6-((2S,3R)-2,3-dimethyl-4-triisopropylsilanyloxy-butyl)-3-methoxymethoxymethyl-cyclohex-2-enyl]-6-hydroxymethyl-2,2-dimethyl-[1,3]dioxan-5-ol

Guidance literature:: With ammonia; sodium; In tetrahydrofuran; at -78 ℃;
DOI:10.1002/anie.200461802

Reference yield:

: 69739-34-0
t-butyldimethylsiyl triflate

: 834916-86-8
(4S,5S,6R)-4-[(1S,6R)-6-(tert-Butyl-dimethyl-silanyloxymethyl)-6-((2S,3R)-2,3-dimethyl-4-triisopropylsilanyloxy-butyl)-3-methoxymethoxymethyl-cyclohex-2-enyl]-6-hydroxymethyl-2,2-dimethyl-[1,3]dioxan-5-ol

Guidance literature:: Multi-step reaction with 2 steps

1: 2,6-lutidine / CH₂Cl₂ / 0 °C

2: 91 percent / Na; liq. NH₃ / tetrahydrofuran / -78 °C

With 2,6-dimethylpyridine; ammonia; sodium; In tetrahydrofuran; dichloromethane;
DOI:10.1002/anie.200461802

Reference yield:

: 834916-83-5
(1R,2S)-1-((2S,3R)-2,3-Dimethyl-4-triisopropylsilanyloxy-butyl)-2-[(S)-hydroxy-((2R,4S,5R)-5-hydroxy-2-phenyl-[1,3]dioxan-4-yl)-methyl]-4-methoxymethoxymethyl-cyclohex-3-enecarbonitrile

: 834916-86-8
(4S,5S,6R)-4-[(1S,6R)-6-(tert-Butyl-dimethyl-silanyloxymethyl)-6-((2S,3R)-2,3-dimethyl-4-triisopropylsilanyloxy-butyl)-3-methoxymethoxymethyl-cyclohex-2-enyl]-6-hydroxymethyl-2,2-dimethyl-[1,3]dioxan-5-ol

Guidance literature:: Multi-step reaction with 4 steps

1.1: 88 percent / CSA / CH₂Cl₂ / 20 °C

2.1: DIBAL-H / toluene / -30 - 20 °C

2.2: SiO₂ / hexane / 20 °C

2.3: DIBAL-H / toluene / -78 - 0 °C

3.1: 2,6-lutidine / CH₂Cl₂ / 0 °C

4.1: 91 percent / Na; liq. NH₃ / tetrahydrofuran / -78 °C

With 2,6-dimethylpyridine; camphor-10-sulfonic acid; ammonia; sodium; diisobutylaluminium hydride; In tetrahydrofuran; dichloromethane; toluene;
DOI:10.1002/anie.200461802