3,4-dichloro-2-iodobenzenamine

Base Information

• Chemical Name: 3,4-dichloro-2-iodobenzenamine
• CAS No.: 835595-11-4
• Molecular Formula: C6H4Cl2IN
• Molecular Weight: 287.915
• Mol file: 835595-11-4.mol

Synonyms:Benzenamine,3,4-dichloro-2-iodo;

Chemical Property of 3,4-dichloro-2-iodobenzenamine

Chemical Property:

• Melting Point: 40 °C
• Boiling Point: 335.7±42.0 °C(Predicted)
• PKA: 0.84±0.10(Predicted)
• PSA: 26.02000
• Density: 2.091±0.06 g/cm3(Predicted)
• LogP: 3.76140
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C

Purity/Quality:

99% ^*data from raw suppliers

3,4-Dichloro-2-iodoaniline 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3,4-dichloro-2-iodobenzenamine

There total 2 articles about 3,4-dichloro-2-iodobenzenamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 15.0%

m,p-dichloroaniline (95-76-1) → 3,4-dichloro-2-iodoaniline (835595-11-4)

Guidance literature:

With hydrogen iodide; dihydrogen peroxide; In water; at 20 ℃; Darkness;

Reference yield:

m,p-dichloroaniline (95-76-1) → 3,4-dichloro-2-iodoaniline (835595-11-4) + 3,4-dichloro-2,6-diiodoaniline (89284-72-0) + 4,5-dichloro-2-iodobenzenamine (220185-63-7)

Guidance literature:

With iodine; silver sulfate; In dichloromethane; at 20 ℃; for 17h; regioselective reaction;

DOI:10.1016/j.tet.2011.07.064

Reference yield: 91.0%

3,4-dichloro-2-iodoaniline (835595-11-4) + 4-tert-butyl-3-fluorobenzene-1-sulfonyl chloride (1452184-05-2) → 4-tert-butyl-N-(3,4-dichloro-2-iodophenyl)-3-fluorobenzsulfonamide

Guidance literature:

3,4-dichloro-2-iodoaniline; 4-tert-butyl-3-fluorobenzene-1-sulfonyl chloride; With pyridine; at 80 ℃;

With sodium hydroxide; In ethanol; water; at 80 ℃; for 2h;

upstream raw materials:

m,p-dichloroaniline

Refernces

• 1、 Joshi, Sudhir N.,Vyas, Sandhya M.,Wu, Huimin,Duffel, Michael W.,Parkin, Sean,Lehmler, Hans-Joachim. "Regioselective iodination of chlorinated aromatic compounds using silver salts". experimental part. p. 7461 - 7469. Retrieved 2011/10/10.