Chemical Property of 2-(2,6-Dioxopiperidin-3-yl)-4-fluoroisoindoline-1,3-dione
Chemical Property:
- Melting Point:254-256°C
- Boiling Point:520.9±45.0 °C(Predicted)
- PKA:10.63±0.40(Predicted)
- PSA：87.04000
- Density:1.570±0.06 g/cm3(Predicted)
- LogP:0.44070
- Storage Temp.:2-8°C
- Solubility.:Dichloromethane (Slightly, Heated), DMSO (Slightly)
- XLogP3:0.4
- Hydrogen Bond Donor Count:1
- Hydrogen Bond Acceptor Count:5
- Rotatable Bond Count:1
- Exact Mass:276.05463493
- Heavy Atom Count:20
- Complexity:507
- Purity/Quality:
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99%, *data from raw suppliers
2-(2,6-dioxopiperidin-3-yl)-4-fluoroisoindoline-1,3-dione 95%-98% *data from reagent suppliers
Safty Information:
- Pictogram(s):
- Hazard Codes:
- MSDS Files:
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SDS file from LookChem
Useful:
- Canonical SMILES:C1CC(=O)NC(=O)C1N2C(=O)C3=C(C2=O)C(=CC=C3)F
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Description
4-Fluoro-thalidomide is the Thalidomide-based Cereblon ligand used in the recruitment of CRBN protein. It can be connected to the ligand for IRAK4 protein by a linker to form PROTAC IRAK4 degrader-1 (HY-129966).
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Uses
2-(2,6-Dioxo-3-piperidinyl)-4-fluoro-1H-isoindole-1,3(2H)-dione is an intermediate in the synthesis of N-[2-Aminoethyl] Pomalidomide TFA Salt (A6095150. N-[2-Aminoethyl] Pomalidomide TFA is a thalidomide derivative, a potent inhibitor of TNF-α production. It is an anti-inflammatory and anti-tumor agent used in the treatment of multiple myeloma.
