Regorafenib (Hydrochloride)

Base Information

Chemical Name:Regorafenib (Hydrochloride)
CAS No.:835621-07-3
Molecular Formula:C21H15ClF4N4O3.ClH
Molecular Weight:519.283
Hs Code.:
Mol file:835621-07-3.mol

Synonyms:Regorafenib HCl;BAY73-4506 hydrochloride;2-Pyridinecarboxamide, 4-[4-[[[[4-chloro-3-(trifluoromethyl)phenyl]amino]carbonyl]amino]-3-fluorophenoxy]-N-methyl-, hydrochloride (1:1);4-[4-[[4-chloro-3-(trifluoromethyl)phenyl]carbamoylamino]-3-fluorophenoxy]-N-methylpyridine-2-carboxamide hydrochloride;

Suppliers and Price of Regorafenib (Hydrochloride)

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

DC Chemicals
Regorafenibhydrochloride >98%
250 mg
$ 400.00

DC Chemicals
Regorafenibhydrochloride >98%
1 g
$ 750.00

DC Chemicals
Regorafenibhydrochloride >98%
100 mg
$ 200.00

Crysdot
RegorafenibHydrochloride 98+%
100mg
$ 585.00

Crysdot
RegorafenibHydrochloride 98+%
50mg
$ 372.00

Crysdot
RegorafenibHydrochloride 98+%
25mg
$ 219.00

ChemScene
Regorafenib(Hydrochloride) 99.58%
50mg
$ 50.00

ChemScene
Regorafenib(Hydrochloride) 99.58%
100mg
$ 80.00

Chemenu
4-(4-(3-(4-Chloro-3-(trifluoromethyl)phenyl)ureido)-3-fluorophenoxy)-N-methylpicolinamidehydrochloride 98%
100mg
$ 203.00

Biorbyt Ltd
Regorafenib hydrochloride
1 g
$ 1133.90

Total 63 raw suppliers

Chemical Property of Regorafenib (Hydrochloride)

Chemical Property:

Appearance/Colour:White to off-white solid
PSA：95.84000
LogP:6.96830

Purity/Quality:

99%, ^*data from raw suppliers

Regorafenibhydrochloride >98% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of Regorafenib (Hydrochloride)

There total 5 articles about Regorafenib (Hydrochloride) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 755037-03-7
regorafenib

: 835621-07-3
4-{4-[3-(4-chloro-3-trifluoromethylphenyl)-ureido]-3-fluorophenoxy}-pyridine-2-carboxylic acid methylamide hydrochloride

Guidance literature:: With hydrogenchloride; In tetrahydrofuran; 1,3-dioxane;

Reference yield:

: 757251-39-1
4-(4-amino-3-fluorophenoxy)pyridine-2-carboxylic acid methyl amide

: C₇H₃ClF₃NO

: 835621-07-3
4-{4-[3-(4-chloro-3-trifluoromethylphenyl)-ureido]-3-fluorophenoxy}-pyridine-2-carboxylic acid methylamide hydrochloride

Guidance literature:: In tetrahydrofuran; at 25 ℃; for 3.41667h; Inert atmosphere;

Reference yield:

: 757251-39-1
4-(4-amino-3-fluorophenoxy)pyridine-2-carboxylic acid methyl amide

: 835621-07-3
4-{4-[3-(4-chloro-3-trifluoromethylphenyl)-ureido]-3-fluorophenoxy}-pyridine-2-carboxylic acid methylamide hydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1: toluene / 72 h / 20 °C

2: hydrogenchloride / 1,4-dioxane; tetrahydrofuran

With hydrogenchloride; In tetrahydrofuran; 1,4-dioxane; toluene;