2-Pyridinecarboxamide, 4-[4-[[[[4-chloro-3-(trifluoromethyl)phenyl]amino]carbonyl]amino]-3-fluoro phenoxy]-N-methyl-, monobenzenesulfonate

Base Information

Chemical Name:2-Pyridinecarboxamide, 4-[4-[[[[4-chloro-3-(trifluoromethyl)phenyl]amino]carbonyl]amino]-3-fluoro phenoxy]-N-methyl-, monobenzenesulfonate
CAS No.:835621-09-5
Molecular Formula:C21H15ClF4N4O3.C6H6O3S
Molecular Weight:641
Hs Code.:

2-Pyridinecarboxamide,
4-[4-[[[[4-chloro-3-(trifluoromethyl)phenyl]amino]carbonyl]amino]-3-fluoro
phenoxy]-N-methyl-, monobenzenesulfonate

Synonyms:

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-Pyridinecarboxamide, 4-[4-[[[[4-chloro-3-(trifluoromethyl)phenyl]amino]carbonyl]amino]-3-fluoro phenoxy]-N-methyl-, monobenzenesulfonate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 2-Pyridinecarboxamide, 4-[4-[[[[4-chloro-3-(trifluoromethyl)phenyl]amino]carbonyl]amino]-3-fluoro phenoxy]-N-methyl-, monobenzenesulfonate

There total 4 articles about 2-Pyridinecarboxamide, 4-[4-[[[[4-chloro-3-(trifluoromethyl)phenyl]amino]carbonyl]amino]-3-fluoro phenoxy]-N-methyl-, monobenzenesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

: 755037-03-7
regorafenib

: 835621-09-5
4-{4-[3-(4-chloro-3-trifluoromethylphenyl)-ureido]-3-fluorophenoxy}-pyridine-2-carboxylic acid methylamide phenylsulfonate

Guidance literature:: With benzenesulfonic acid; In ethanol;

Reference yield: 69.0%

: 755037-03-7
regorafenib

: 98-11-3
benzenesulfonic acid

: 835621-09-5
4-{4-[3-(4-chloro-3-trifluoromethylphenyl)-ureido]-3-fluorophenoxy}-pyridine-2-carboxylic acid methylamide phenylsulfonate

Guidance literature:: In ethanol; Heating;

Reference yield:

: 394-41-2
3-fluoro-4-nitrophenol

: 835621-09-5
4-{4-[3-(4-chloro-3-trifluoromethylphenyl)-ureido]-3-fluorophenoxy}-pyridine-2-carboxylic acid methylamide phenylsulfonate

Guidance literature:: Multi-step reaction with 4 steps

1.1: hydrogen / palladium 10% on activated carbon / ethyl acetate / 4 h

2.1: potassium tert-butylate / N,N-dimethyl acetamide / 0.42 h / 0 °C

2.2: 16 h / 100 °C

3.1: toluene / 72 h / 20 °C

4.1: ethanol / Heating

With potassium tert-butylate; hydrogen; palladium 10% on activated carbon; In ethanol; N,N-dimethyl acetamide; ethyl acetate; toluene;