Pyrazine, 2-[(1R)-1-[(1R,2R)-2-[[(1,1-dimethylethyl)dimethylsilyl]oxy]cyclopropyl]-2 -(phenylsulfonyl)ethyl]-2,5-dihydro-3,6-dimethoxy-5-(1-methylethyl)-, (2S,5R)-

Base Information

Chemical Name:Pyrazine, 2-[(1R)-1-[(1R,2R)-2-[[(1,1-dimethylethyl)dimethylsilyl]oxy]cyclopropyl]-2 -(phenylsulfonyl)ethyl]-2,5-dihydro-3,6-dimethoxy-5-(1-methylethyl)-, (2S,5R)-
CAS No.:835629-40-8
Molecular Formula:C26H42N2O5SSi
Molecular Weight:522.781
Hs Code.:

Pyrazine,
2-[(1R)-1-[(1R,2R)-2-[[(1,1-dimethylethyl)dimethylsilyl]oxy]cyclopropyl]-2
-(phenylsulfonyl)ethyl]-2,5-dihydro-3,6-dimethoxy-5-(1-methylethyl)-,
(2S,5R)-

Synonyms:

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Pyrazine, 2-[(1R)-1-[(1R,2R)-2-[[(1,1-dimethylethyl)dimethylsilyl]oxy]cyclopropyl]-2 -(phenylsulfonyl)ethyl]-2,5-dihydro-3,6-dimethoxy-5-(1-methylethyl)-, (2S,5R)-

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Technology Process of Pyrazine, 2-[(1R)-1-[(1R,2R)-2-[[(1,1-dimethylethyl)dimethylsilyl]oxy]cyclopropyl]-2 -(phenylsulfonyl)ethyl]-2,5-dihydro-3,6-dimethoxy-5-(1-methylethyl)-, (2S,5R)-

There total 1 articles about Pyrazine, 2-[(1R)-1-[(1R,2R)-2-[[(1,1-dimethylethyl)dimethylsilyl]oxy]cyclopropyl]-2 -(phenylsulfonyl)ethyl]-2,5-dihydro-3,6-dimethoxy-5-(1-methylethyl)-, (2S,5R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 109838-85-9
(2R)-2,5-dihydro-2-isopropyl-3,6-dimethoxypyrazine

: 527729-63-1
(-)-(1R,2R)-2-(2-benzenesulfonylvinyl)-1-tert-butyldimethylsililoxy-cyclopropane

: 835629-40-8
(2S,5R,1'R,1''R,2''R)-2-{2'-benzenesulfonyl-1'-[2''-(tert-butyldimethylsilanyloxy)-cyclopropyl]-ethyl}-5-isopropyl-3,6-dimethoxy-2,5-dihydro-pyrazine

Guidance literature:: (2R)-2,5-dihydro-2-isopropyl-3,6-dimethoxypyrazine; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 0.333333h;

(-)-(1R,2R)-2-(2-benzenesulfonylvinyl)-1-tert-butyldimethylsililoxy-cyclopropane; In tetrahydrofuran; hexane; at -78 ℃; for 0.5h;
DOI:10.1016/j.tet.2004.10.072

Reference yield: 84.0%

: 835629-40-8
(2S,5R,1'R,1''R,2''R)-2-{2'-benzenesulfonyl-1'-[2''-(tert-butyldimethylsilanyloxy)-cyclopropyl]-ethyl}-5-isopropyl-3,6-dimethoxy-2,5-dihydro-pyrazine

: 835629-42-0
(2S,5R,2'R,1''R,2''R)-2'-[2-amino-4-benzenesulfonyl-3-(2''-hydroxy-cyclopropyl)-butyrylamino]-3'-methyl-butyric acid methyl ester

Guidance literature:: (2S,5R,1'R,1''R,2''R)-2-{2'-benzenesulfonyl-1'-[2''-(tert-butyldimethylsilanyloxy)-cyclopropyl]-ethyl}-5-isopropyl-3,6-dimethoxy-2,5-dihydro-pyrazine; With tetrabutyl ammonium fluoride; In tetrahydrofuran; for 1h;

With hydrogenchloride; In tetrahydrofuran; at 20 ℃; for 3h;
DOI:10.1016/j.tet.2004.10.072

Reference yield: 60.0%

: 835629-40-8
(2S,5R,1'R,1''R,2''R)-2-{2'-benzenesulfonyl-1'-[2''-(tert-butyldimethylsilanyloxy)-cyclopropyl]-ethyl}-5-isopropyl-3,6-dimethoxy-2,5-dihydro-pyrazine

: (2S,5R,1'R,1''R,2''R)-2-[2'-benzenesulfonyl-1'-(2''-hydroxy-cyclopropyl)-ethyl]-5-isopropyl-6-methoxy-2,5-dihydro-1H-pyrazin-3-one

: 835629-42-0
(2S,5R,2'R,1''R,2''R)-2'-[2-amino-4-benzenesulfonyl-3-(2''-hydroxy-cyclopropyl)-butyrylamino]-3'-methyl-butyric acid methyl ester

Guidance literature:: (2S,5R,1'R,1''R,2''R)-2-{2'-benzenesulfonyl-1'-[2''-(tert-butyldimethylsilanyloxy)-cyclopropyl]-ethyl}-5-isopropyl-3,6-dimethoxy-2,5-dihydro-pyrazine; With tetrabutyl ammonium fluoride; In tetrahydrofuran; for 1h;

With hydrogenchloride; In tetrahydrofuran; at 20 ℃; for 1h;
DOI:10.1016/j.tet.2004.10.072