Benzenamine, 3-methoxy-4-[(1-methyl-4-piperidinyl)methoxy]-

Base Information

• Chemical Name: Benzenamine, 3-methoxy-4-[(1-methyl-4-piperidinyl)methoxy]-
• CAS No.: 835633-71-1
• Molecular Formula: C14H22N2O2
• Molecular Weight: 250.341

Synonyms:N-methyl-4-(2-methoxy-4-aminophenoxymethyl)piperidine;3-Methoxy-4-(1-methyl-piperidin-4-ylmethoxy)-phenylamine;

Chemical Property of Benzenamine, 3-methoxy-4-[(1-methyl-4-piperidinyl)methoxy]-

Chemical Property:

• Boiling Point: 380.9±22.0 °C(Predicted)
• PSA: 47.72000
• Density: 1.073±0.06 g/cm3(Predicted)
• LogP: 2.51710

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Benzenamine, 3-methoxy-4-[(1-methyl-4-piperidinyl)methoxy]-

There total 2 articles about Benzenamine, 3-methoxy-4-[(1-methyl-4-piperidinyl)methoxy]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

N-methyl-4-(2-methoxy-4-nitrophenoxymethyl)piperidine (835633-52-8) → N-methyl-4-(4-amino-2-methoxy-phenoxymethyl)piperidine (835633-71-1)

Guidance literature:

With hydrogen; palladium on activated carbon; In ethanol;

Reference yield:

→ N-methyl-4-(4-amino-2-methoxy-phenoxymethyl)piperidine (835633-71-1)

Guidance literature:

Reference yield: 72.0%

N-methyl-4-(4-amino-2-methoxy-phenoxymethyl)piperidine (835633-71-1) + 5-amino-4,6-dichloropyridimine (5413-85-4) → 6-chloro-N4-[3-methoxy-4-(1-methyl-piperidin-4-ylmethoxy)-phenyl]-pyrimidine-4,5-diamine

Guidance literature:

With hydrogenchloride; In ethanol; water; for 24h; Heating;

DOI:10.1021/jo051419g

upstream raw materials:

N-methyl-4-(2-methoxy-4-nitrophenoxymethyl)piperidine

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