Carbamic acid, [[1-[(3R)-3-(3,5-difluorophenyl)-3-[1-(methylsulfonyl)-4-piperidinyl]propyl] -4-piperidinyl]methyl]-, 1,1-dimethylethyl ester

Base Information

Chemical Name:Carbamic acid, [[1-[(3R)-3-(3,5-difluorophenyl)-3-[1-(methylsulfonyl)-4-piperidinyl]propyl] -4-piperidinyl]methyl]-, 1,1-dimethylethyl ester
CAS No.:835876-97-6
Molecular Formula:C26H41F2N3O4S
Molecular Weight:529.692
Hs Code.:

Carbamic acid,
[[1-[(3R)-3-(3,5-difluorophenyl)-3-[1-(methylsulfonyl)-4-piperidinyl]propyl]
-4-piperidinyl]methyl]-, 1,1-dimethylethyl ester

Synonyms:

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Chemical Property of Carbamic acid, [[1-[(3R)-3-(3,5-difluorophenyl)-3-[1-(methylsulfonyl)-4-piperidinyl]propyl] -4-piperidinyl]methyl]-, 1,1-dimethylethyl ester

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Technology Process of Carbamic acid, [[1-[(3R)-3-(3,5-difluorophenyl)-3-[1-(methylsulfonyl)-4-piperidinyl]propyl] -4-piperidinyl]methyl]-, 1,1-dimethylethyl ester

There total 7 articles about Carbamic acid, [[1-[(3R)-3-(3,5-difluorophenyl)-3-[1-(methylsulfonyl)-4-piperidinyl]propyl] -4-piperidinyl]methyl]-, 1,1-dimethylethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 718610-25-4
(R) 3-(1-methanesulphonylpiperidin-4-yl)-3-[3,5-difluorophenyl]propionaldehyde

: 135632-53-0
tert-butyl N-(4-piperidinylmethyl)carbamate

: 835876-97-6
tert-butyl [(1-{(3R)-3-(3,5-difluorophenyl)-3-[1-(methylsulfonyl)-piperidin-4-yl]propyl}piperidin-4-yl)methyl]carbamate

Guidance literature:: With sodium tris(acetoxy)borohydride; In dichloromethane; for 4h;

Reference yield:

: 718610-70-9
N-(benzyloxycarbonylpiperidin-4-yl)propenoic acid isopropyl ester

: 835876-97-6
tert-butyl [(1-{(3R)-3-(3,5-difluorophenyl)-3-[1-(methylsulfonyl)-piperidin-4-yl]propyl}piperidin-4-yl)methyl]carbamate

Guidance literature:: Multi-step reaction with 6 steps

1: (R)-2,2'-bis(diphenylphosphanyl)-1,1'-binaphthyl / acetylacetonatobis(ethylene)rhodium(I) / 1,4-dioxane / 18.67 h / 100 °C

2: hydrogen / palladium(II) hydroxide/carbon / ethanol

3: triethylamine / dichloromethane / 0 - 20 °C

4: lithium aluminium tetrahydride / tetrahydrofuran / 0.75 h / -10 °C

5: Dess-Martin periodane / dichloromethane / 1.5 h

6: sodium tris(acetoxy)borohydride / dichloromethane / 4 h

With lithium aluminium tetrahydride; hydrogen; sodium tris(acetoxy)borohydride; Dess-Martin periodane; (R)-2,2'-bis(diphenylphosphanyl)-1,1'-binaphthyl; triethylamine; acetylacetonatobis(ethylene)rhodium(I); palladium(II) hydroxide/carbon; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane;

Reference yield:

: 718610-71-0
(R)-3-[N-(benzyloxycarbonyl)piperidin-4-yl]-3-(3,5-difluorophenyl)propanoic acid isopropyl ester

: 835876-97-6
tert-butyl [(1-{(3R)-3-(3,5-difluorophenyl)-3-[1-(methylsulfonyl)-piperidin-4-yl]propyl}piperidin-4-yl)methyl]carbamate

Guidance literature:: Multi-step reaction with 5 steps

1: hydrogen / palladium(II) hydroxide/carbon / ethanol

2: triethylamine / dichloromethane / 0 - 20 °C

3: lithium aluminium tetrahydride / tetrahydrofuran / 0.75 h / -10 °C

4: Dess-Martin periodane / dichloromethane / 1.5 h

5: sodium tris(acetoxy)borohydride / dichloromethane / 4 h

With lithium aluminium tetrahydride; hydrogen; sodium tris(acetoxy)borohydride; Dess-Martin periodane; triethylamine; palladium(II) hydroxide/carbon; In tetrahydrofuran; ethanol; dichloromethane;