2-(benzyloxy)-5-bromobenzonitrile

Base Information

• Chemical Name: 2-(benzyloxy)-5-bromobenzonitrile
• CAS No.: 835898-37-8
• Molecular Formula: C₁₄H₁₀BrNO
• Molecular Weight: 288.143
• Mol file: 835898-37-8.mol

Synonyms:

Chemical Property of 2-(benzyloxy)-5-bromobenzonitrile

Chemical Property:

• PSA: 33.02000
• LogP: 3.89978

Purity/Quality:

99% ^*data from raw suppliers

2-Benzyloxy-5-bromobenzonitrile 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-(benzyloxy)-5-bromobenzonitrile

There total 1 articles about 2-(benzyloxy)-5-bromobenzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ 1-(benzyloxy)-4-bromo-2-cyanobenzene (835898-37-8)

Guidance literature:

Reference yield:

1-(benzyloxy)-4-bromo-2-cyanobenzene (835898-37-8) → tert-butyl (E)-(2-(4-(1-(4-(benzyloxy)-3-cyanophenyl)-2-phenylbut-1-en-1-yl)phenoxy)ethyl)carbamate

Guidance literature:

Multi-step reaction with 2 steps

1.1: copper(l) iodide; caesium carbonate; bis-triphenylphosphine-palladium(II) chloride / methanol; water; N,N-dimethyl acetamide / 5 h / 90 °C / Sealed tube; Inert atmosphere

2.1: bis(pinacol)diborane; tetrakis(triphenylphosphine)platinum / 2-methyltetrahydrofuran / 12 h / 90 °C / Inert atmosphere

2.2: 6 h / 20 °C / Inert atmosphere

2.3: 12 h / 80 °C / Inert atmosphere

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; tetrakis(triphenylphosphine)platinum; caesium carbonate; bis(pinacol)diborane; In 2-methyltetrahydrofuran; methanol; N,N-dimethyl acetamide; water;

Reference yield:

1-(benzyloxy)-4-bromo-2-cyanobenzene (835898-37-8) → (E)-5-(1-(4-(2-aminoethoxy)phenyl)-2-phenylbut-1en-1-yl)-2-(benzyloxy)benzonitrile

Guidance literature:

Multi-step reaction with 3 steps

1.1: copper(l) iodide; caesium carbonate; bis-triphenylphosphine-palladium(II) chloride / methanol; water; N,N-dimethyl acetamide / 5 h / 90 °C / Sealed tube; Inert atmosphere

2.1: bis(pinacol)diborane; tetrakis(triphenylphosphine)platinum / 2-methyltetrahydrofuran / 12 h / 90 °C / Inert atmosphere

2.2: 6 h / 20 °C / Inert atmosphere

2.3: 12 h / 80 °C / Inert atmosphere

3.1: hydrogenchloride / dichloromethane; diethyl ether / 3 h / 0 - 20 °C

With hydrogenchloride; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; tetrakis(triphenylphosphine)platinum; caesium carbonate; bis(pinacol)diborane; In 2-methyltetrahydrofuran; methanol; diethyl ether; dichloromethane; N,N-dimethyl acetamide; water;

Refernces

• 1、 -. "2-PHENYLPYRIDINE DERIVATIVE". Page/Page column 27; 32. . Retrieved 2008/06/13.