AS1842856

Base Information

Chemical Name:AS1842856
CAS No.:836620-48-5
Molecular Formula:C₁₈H₂₂FN₃O₃
Molecular Weight:347.389
Hs Code.:
Mol file:836620-48-5.mol

Synonyms:5-Amino-7-(cyclohexylamino)-1-ethyl-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid;

Suppliers and Price of AS1842856

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
AS1842856
10mg
$ 95.00

Tocris
AS1842856 ≥98%(HPLC)
10
$ 95.00

DC Chemicals
AS1842856 >98%
1 g
$ 1600.00

Cayman Chemical
AS-1842856 ≥98%
5mg
$ 68.00

Cayman Chemical
AS-1842856 ≥98%
1mg
$ 27.00

Cayman Chemical
AS-1842856 ≥98%
10mg
$ 95.00

Axon Medchem
AS1842856 99%
2 x 10 mg
$ 154.00

Axon Medchem
AS1842856 99%
50 mg
$ 368.50

Axon Medchem
AS1842856 99%
10 mg
$ 104.50

American Custom Chemicals Corporation
AS-1842856 95.00%
5MG
$ 452.03

Total 14 raw suppliers

Chemical Property of AS1842856

Chemical Property:

Boiling Point:587.3±50.0 °C(Predicted)
PKA:6.47±0.50(Predicted)
PSA：97.35000
Density:1.370±0.06 g/cm3(Predicted)
LogP:3.83970
Storage Temp.:Keep in dark place,Inert atmosphere,Store in freezer, under -20°C

Purity/Quality:

99%, ^*data from raw suppliers

AS1842856 ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Description AS-1842856 is a potent inhibitor of forkhead box class O transcription factor 1 (FoxO1; IC50 = 33 nM in HepG2 cells). Inhibition of FoxO1-mediated transactivation with AS-1842856 leads to a dose-dependent decrease in expression of glucose-6 phosphatase (G6Pase) and phosphoenolpyruvate carboxykinase (PEPCK) mRNA and inhibits glucogenesis in rat hepatoma Fao cells and a murine model of type 2 diabetes mellitus (T2DM). AS-1842856 also inhibits 3T3-L1 preadipocyte differentiation and reduces lipid droplet growth in adipocytes.,
Uses AS 1842856 is a novel FoxO1 antagonist with anti-obesity effects.

Technology Process of AS1842856

There total 8 articles about AS1842856 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 9.6%

: 131683-96-0
5-amino-1-ethyl-6,7-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid

: 108-91-8,157973-60-9
cyclohexylamine

: 836620-48-5
AS 1842856

Guidance literature:: With triethylamine; In dimethyl sulfoxide; at 100 ℃; for 16h;

Reference yield:

: 163733-96-8
3,4,5-trifluoro aniline

: 836620-48-5
AS 1842856

Guidance literature:: Multi-step reaction with 7 steps

1: 3 h / 120 °C

2: diphenylether / 3 h / 250 °C

3: potassium carbonate / N,N-dimethyl-formamide / 3 h / 68 °C

4: triethylamine / toluene / 4 h / 100 °C

5: acetic acid; palladium 10% on activated carbon; hydrogen / ethanol / 30 - 40 °C / 760.05 Torr

6: hydrogenchloride / water / 6 h / 100 °C

7: triethylamine / dimethyl sulfoxide / 16 h / 100 °C

With hydrogenchloride; palladium 10% on activated carbon; hydrogen; potassium carbonate; acetic acid; triethylamine; In diphenylether; ethanol; water; dimethyl sulfoxide; N,N-dimethyl-formamide; toluene;

Reference yield:

: 950727-18-1
diethyl [[(3,4,5-trifluorophenyl)amino]methylene]malonate

: 836620-48-5
AS 1842856

Guidance literature:: Multi-step reaction with 6 steps

1: diphenylether / 3 h / 250 °C

2: potassium carbonate / N,N-dimethyl-formamide / 3 h / 68 °C

3: triethylamine / toluene / 4 h / 100 °C

4: acetic acid; palladium 10% on activated carbon; hydrogen / ethanol / 30 - 40 °C / 760.05 Torr

5: hydrogenchloride / water / 6 h / 100 °C

6: triethylamine / dimethyl sulfoxide / 16 h / 100 °C

With hydrogenchloride; palladium 10% on activated carbon; hydrogen; potassium carbonate; acetic acid; triethylamine; In diphenylether; ethanol; water; dimethyl sulfoxide; N,N-dimethyl-formamide; toluene;