Cinchoninamide, 2-butoxy-N-(2-(1-pyrrolidinyl)ethyl)-

Base Information

Chemical Name:Cinchoninamide, 2-butoxy-N-(2-(1-pyrrolidinyl)ethyl)-
CAS No.:67547-91-5
Molecular Formula:C20H27N3O2
Molecular Weight:341.4473
Hs Code.:
DSSTox Substance ID:DTXSID00217878
Wikidata:Q83094574
ChEMBL ID:CHEMBL4765004

Synonyms:BRN 0430400;Cinchoninamide, 2-butoxy-N-(2-(1-pyrrolidinyl)ethyl)-;2-Butoxy-N-(2-(1-pyrrolidinyl)ethyl)cinchoninamide;4-Quinolinecarboxamide, 2-butoxy-N-(2-(1-pyrrolidinyl)ethyl)-;67547-91-5;CHEMBL4765004;DTXSID00217878;LS-53771

Suppliers and Price of Cinchoninamide, 2-butoxy-N-(2-(1-pyrrolidinyl)ethyl)-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemical Property of Cinchoninamide, 2-butoxy-N-(2-(1-pyrrolidinyl)ethyl)-

Chemical Property:

Vapor Pressure:5.85E-11mmHg at 25°C
Boiling Point:521.1°Cat760mmHg
Flash Point:269°C
Density:1.127g/cm³
XLogP3:4.2
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:8
Exact Mass:341.21032711
Heavy Atom Count:25
Complexity:412

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCCCOC1=NC2=CC=CC=C2C(=C1)C(=O)NCCN3CCCC3

Technology Process of Cinchoninamide, 2-butoxy-N-(2-(1-pyrrolidinyl)ethyl)-

There total 4 articles about Cinchoninamide, 2-butoxy-N-(2-(1-pyrrolidinyl)ethyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 26.8%

: 2-chloro-N-(2-(pyrrolidin-1-yl)ethyl)quinoline-4-carboxamide

: 71-36-3
butan-1-ol

: 67547-91-5
2-butoxy-N-(2-(pyrrolidin-1-yl)ethyl)quinoline-4-carboxamide

Guidance literature:: butan-1-ol; With sodium hydride; for 0.5h; Inert atmosphere;

2-chloro-N-(2-(pyrrolidin-1-yl)ethyl)quinoline-4-carboxamide; With potassium iodide; In N,N-dimethyl-formamide; at 80 ℃; for 72h; Inert atmosphere;
DOI:10.1016/j.ejmech.2020.112310

Reference yield: 26.8%

: 67547-91-5
2-butoxy-N-(2-(pyrrolidin-1-yl)ethyl)quinoline-4-carboxamide

Guidance literature:: With sodium hydride; In N,N-dimethyl-formamide; at 20 ℃; for 0.5h; Inert atmosphere; Cooling with ice;

With potassium iodide; In N,N-dimethyl-formamide; at 80 ℃; for 72h; Inert atmosphere;

Reference yield:

: 2388-32-1
2-chloroquinoline-4-carbonyl chloride

: 67547-91-5
2-butoxy-N-(2-(pyrrolidin-1-yl)ethyl)quinoline-4-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: triethylamine / dichloromethane

2.1: sodium hydride / 0.5 h / Inert atmosphere

2.2: 72 h / 80 °C / Inert atmosphere

With sodium hydride; triethylamine; In dichloromethane;
DOI:10.1016/j.ejmech.2020.112310