Decanoic acid, 10-hydroxy-4-[2-(trimethylsilyl)ethoxy]-, (1R,2S,5R)-5-methyl-2-(1-methyl-1-phenylethyl)cyclohexyl ester, (4R)-

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Chemical Name:Decanoic acid, 10-hydroxy-4-[2-(trimethylsilyl)ethoxy]-, (1R,2S,5R)-5-methyl-2-(1-methyl-1-phenylethyl)cyclohexyl ester, (4R)-
CAS No.:837428-47-4
Molecular Formula:C31H54O4Si
Molecular Weight:518.853
Hs Code.:

Synonyms:

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Chemical Property of Decanoic acid, 10-hydroxy-4-[2-(trimethylsilyl)ethoxy]-, (1R,2S,5R)-5-methyl-2-(1-methyl-1-phenylethyl)cyclohexyl ester, (4R)-

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Technology Process of Decanoic acid, 10-hydroxy-4-[2-(trimethylsilyl)ethoxy]-, (1R,2S,5R)-5-methyl-2-(1-methyl-1-phenylethyl)cyclohexyl ester, (4R)-

There total 15 articles about Decanoic acid, 10-hydroxy-4-[2-(trimethylsilyl)ethoxy]-, (1R,2S,5R)-5-methyl-2-(1-methyl-1-phenylethyl)cyclohexyl ester, (4R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 837428-41-8
(4R)-4-[2-(trimethylsilyl)ethoxy]decanedioic acid 1-[(1R,2S,5R)-5-methyl-2-(1-methyl-1-phenylethyl)cyclohexyl] ester

: 837428-47-4
(1R,2S,5R)-5-methyl-2-(1-methyl-1-phenylethyl)cyclohexyl (4R)-10-hydroxy-4-[2-(trimethylsilyl)ethoxy]decanoate

Guidance literature:: With dimethylsulfide borane complex; In tetrahydrofuran; dichloromethane; at 20 ℃; for 12h;
DOI:10.1021/ol0479242

Reference yield:

: 100-73-2
acrolein dimer

: 837428-47-4
(1R,2S,5R)-5-methyl-2-(1-methyl-1-phenylethyl)cyclohexyl (4R)-10-hydroxy-4-[2-(trimethylsilyl)ethoxy]decanoate

Guidance literature:: Multi-step reaction with 7 steps

1: KHMDS; 18-crown-6 / tetrahydrofuran; toluene / 7 h / -78 °C

2: 81 percent / p-toluenesulfonic acid monohydrate; water / tetrahydrofuran / 20 h / 32 °C

3: LiHMDS / toluene; tetrahydrofuran / 14 h / 0 °C

4: 91 percent / imidazole; DMAP / 1,2-dichloro-ethane; tetrahydrofuran / 16 h / 60 °C

5: neocuproine / Pd₂(dba)3 / CH₂Cl₂ / 3 h / 20 °C

6: 90 percent / hydrogen / Pd on activated carbon / hexane / 48 h / 20 °C

7: 100 percent / BH₃*DMS / tetrahydrofuran; CH₂Cl₂ / 12 h / 20 °C

With 1H-imidazole; dmap; 2.9-dimethyl-1,10-phenanthroline; 18-crown-6 ether; dimethylsulfide borane complex; water; hydrogen; potassium hexamethylsilazane; toluene-4-sulfonic acid; lithium hexamethyldisilazane; palladium on activated charcoal; tris(dibenzylideneacetone)dipalladium ⁽⁰⁾; In tetrahydrofuran; hexane; dichloromethane; 1,2-dichloro-ethane; toluene; 3: Horner-Wadsworth-Emmons reaction;
DOI:10.1021/ol0479242

Reference yield:

: 2916-68-9
2-(Trimethylsilyl)ethanol

: 837428-47-4
(1R,2S,5R)-5-methyl-2-(1-methyl-1-phenylethyl)cyclohexyl (4R)-10-hydroxy-4-[2-(trimethylsilyl)ethoxy]decanoate

Guidance literature:: Multi-step reaction with 3 steps

1: neocuproine / Pd₂(dba)3 / CH₂Cl₂ / 3 h / 20 °C

2: 90 percent / hydrogen / Pd on activated carbon / hexane / 48 h / 20 °C

3: 100 percent / BH₃*DMS / tetrahydrofuran; CH₂Cl₂ / 12 h / 20 °C

With 2.9-dimethyl-1,10-phenanthroline; dimethylsulfide borane complex; hydrogen; palladium on activated charcoal; tris(dibenzylideneacetone)dipalladium ⁽⁰⁾; In tetrahydrofuran; hexane; dichloromethane;
DOI:10.1021/ol0479242