2-DIAZO-3-KETOGLUTARIC ACID DIMETHYL ESTER

Base Information

• Chemical Name: 2-DIAZO-3-KETOGLUTARIC ACID DIMETHYL ESTER
• CAS No.: 83878-89-1
• Molecular Formula: C7H8N2O5
• Molecular Weight: 200.151
• Hs Code.: 2927000090
• Mol file: 83878-89-1.mol

Synonyms:2-diazo-3-ketoglutaric acid dimethyl ester;methyl 2-diazobenzoylacetate;1,5-DIMETHYL 2-DIAZO-3-OXOPENTANEDIOATE;DIMETHYL 2-DIAZO-3-OXOPENTANEDIOATE;2-diazo-3-oxo-pentanedioic acid dimethyl ester;

Chemical Property of 2-DIAZO-3-KETOGLUTARIC ACID DIMETHYL ESTER

Chemical Property:

• PSA: 103.81000
• LogP: 0.21768

Purity/Quality:

98%min ^*data from raw suppliers

2-DIAZO-3-KETOGLUTARIC ACID DIMETHYL ESTER 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-DIAZO-3-KETOGLUTARIC ACID DIMETHYL ESTER

There total 2 articles about 2-DIAZO-3-KETOGLUTARIC ACID DIMETHYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

3-oxopentanedioic acid dimethyl ester (1830-54-2) → 2-diazo-3-oxo-pentanedioic acid dimethyl ester (83878-89-1)

Guidance literature:

With 4-acetamidobenzenesulfonyl azide; triethylamine; In dichloromethane; at 0 - 20 ℃; for 1.5h;

DOI:10.1055/s-0032-1318309

Reference yield:

3-oxopentanedioic acid dimethyl ester (1830-54-2) + 4-acetamidobenzenesulfonyl azide (2158-14-7) → 2-diazo-3-oxo-pentanedioic acid dimethyl ester (83878-89-1)

Guidance literature:

With triethylamine; In diethyl ether; hexane; acetonitrile;

Reference yield: 87.0%

2-diazo-3-oxo-pentanedioic acid dimethyl ester (83878-89-1) → dimethyl 4-hydroxy-1H-pyrazole-3,5-dicarboxylate (23705-85-3)

Guidance literature:

With triethylamine; In benzene; at 80 - 81 ℃; for 1h;

DOI:10.1039/c3ob42102c

upstream raw materials:

3-oxopentanedioic acid dimethyl ester

4-acetamidobenzenesulfonyl azide

Downstream raw materials:

4,6-dihydroxy-pyridazine-3-carboxylic acid methyl ester

{(1S,2R)-2-[6-carbamoyl-5-(1-methyl-1H-pyrazol-3-ylamino)-pyridazin-3-ylamino]-cyclohexyl}-carbamic acid tert-butyl ester

6-((1R,2S)-2-amino-cyclohexylamino)-4-(1-methyl-1H-pyrazol-3-ylamino)-pyridazine-3-carboxylic acid amide

6-((1R,2S)-2-amino-cyclohexylamino)-4-(5,6-dimethoxy-pyridin-2-ylamino)-pyridazine-3-carboxylic acid amide

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