5-Bromo-3-chlorophenylene-1,2-diamine, 5-Bromo-3-chloro-1,2-diaminobenzene

Base Information

• Chemical Name: 5-Bromo-3-chlorophenylene-1,2-diamine, 5-Bromo-3-chloro-1,2-diaminobenzene
• CAS No.: 16429-44-0
• Molecular Formula: C6H6 Br Cl N2
• Molecular Weight: 221.484
• Hs Code.: 2921590090
• Mol file: 16429-44-0.mol

Synonyms:o-Phenylenediamine,5-bromo-3-chloro- (8CI); NSC 522091

Chemical Property of 5-Bromo-3-chlorophenylene-1,2-diamine, 5-Bromo-3-chloro-1,2-diaminobenzene

Chemical Property:

• Vapor Pressure: 0.00079mmHg at 25°C
• Melting Point: 57-60°C
• Boiling Point: 306.1°C at 760 mmHg
• PKA: 2.03±0.10(Predicted)
• Flash Point: 138.9°C
• PSA: 52.04000
• Density: 1.813g/cm³
• LogP: 3.42930
• Storage Temp.: 2-8°C

Purity/Quality:

98%,99%, ^*data from raw suppliers

5-Bromo-3-chlorobenzene-1,2-diamine ^*data from reagent suppliers

Safty Information:

• Hazard Codes: C
• Statements: 34-43
• Safety Statements: 26-36/37/39-45

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-Bromo-3-chlorophenylene-1,2-diamine, 5-Bromo-3-chloro-1,2-diaminobenzene

There total 3 articles about 5-Bromo-3-chlorophenylene-1,2-diamine, 5-Bromo-3-chloro-1,2-diaminobenzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-chloro-4-bromo-6-nitroaniline (34033-41-5) → 3-chloro-5-bromo-1,2-diaminobenzene (16429-44-0)

Guidance literature:

With nickel; hydrazine hydrate;

Reference yield:

4-Bromo-2-nitroaniline (875-51-4) → 3-chloro-5-bromo-1,2-diaminobenzene (16429-44-0)

Guidance literature:

Multi-step reaction with 2 steps

1: N-chloro-succinimide / N,N-dimethyl-formamide / 16 h / 120 °C

2: hydrogenchloride; iron / methanol / 16 h / 8 - 16 °C

With hydrogenchloride; N-chloro-succinimide; iron; In methanol; N,N-dimethyl-formamide;

Reference yield:

→ 3-chloro-5-bromo-1,2-diaminobenzene (16429-44-0)

Guidance literature:

2-Chlor-4-brom-6-nitranilin, Zn/HCl, Red.;

upstream raw materials:

2-chloro-4-bromo-6-nitroaniline

4-Bromo-2-nitroaniline

Downstream raw materials:

6-bromo-4-chloro-2-phenyl-1H-benzo[d]imidazole

2-p-methylphenacylthio-4-chloro-6-bromobenzimidazole

2-phenacylthio-4-chloro-6-bromobenzimidazole

3-phenyl-6-bromo-8-chlorothiazolo<3,2-a>benzimidazole

Refernces

• 1、 -. "2-AMINO-BENZIMIDAZOLE DERIVATIVES AND THEIR USE AS 5-LIPOXYGENASE AND/OR PROSTAGLANDIN E SYNTHASE INHIBITORS". Page/Page column 59. . Retrieved 2016/03/12.