Technology Process of Phenol,
2-chloro-4-[6,9-difluoro-8-(2-methoxyethoxy)-1-methyl-3H-pyrazolo[3,4-
c]isoquinolin-5-yl]-5-fluoro-
There total 5 articles about Phenol,
2-chloro-4-[6,9-difluoro-8-(2-methoxyethoxy)-1-methyl-3H-pyrazolo[3,4-
c]isoquinolin-5-yl]-5-fluoro- which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
zinc trifluoromethanesulfonate;
In
1,2-dichloro-ethane; acetonitrile;
at 120 ℃;
for 18h;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: phosphorus tribromide / toluene / 15 h / 20 °C
2.1: dimethyl sulfoxide / 1 h / 20 °C
3.1: potassium fluoride / N,N-dimethyl-formamide / 15 h / 20 °C
4.1: sodium hydride / tetrahydrofuran / 0.25 h / 20 °C
4.2: 0.25 h / 40 °C
5.1: hydrazine dihydrochloride; triethylamine / ethanol / 6 h / 75 °C
6.1: zinc trifluoromethanesulfonate / 1,2-dichloro-ethane; acetonitrile / 18 h / 120 °C
With
potassium fluoride; hydrazine dihydrochloride; phosphorus tribromide; zinc trifluoromethanesulfonate; sodium hydride; triethylamine;
In
tetrahydrofuran; ethanol; dimethyl sulfoxide; 1,2-dichloro-ethane; N,N-dimethyl-formamide; toluene; acetonitrile;
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: sodium tetrahydroborate; ethanol / 0.5 h / 0 - 20 °C
2.1: phosphorus tribromide / toluene / 15 h / 20 °C
3.1: dimethyl sulfoxide / 1 h / 20 °C
4.1: potassium fluoride / N,N-dimethyl-formamide / 15 h / 20 °C
5.1: sodium hydride / tetrahydrofuran / 0.25 h / 20 °C
5.2: 0.25 h / 40 °C
6.1: hydrazine dihydrochloride; triethylamine / ethanol / 6 h / 75 °C
7.1: zinc trifluoromethanesulfonate / 1,2-dichloro-ethane; acetonitrile / 18 h / 120 °C
With
potassium fluoride; sodium tetrahydroborate; hydrazine dihydrochloride; ethanol; phosphorus tribromide; zinc trifluoromethanesulfonate; sodium hydride; triethylamine;
In
tetrahydrofuran; ethanol; dimethyl sulfoxide; 1,2-dichloro-ethane; N,N-dimethyl-formamide; toluene; acetonitrile;