1-Piperidinecarboxylic acid, 4-[[[5-[3-chloro-4-(phenylmethoxy)phenyl]-3-(1,1-dimethylethyl)-6-fluoro- 7-methoxy-1-methyl-3H-pyrazolo[3,4-c]isoquinolin-8-yl]oxy]methyl]-, 1,1-dimethylethyl ester

Base Information

Chemical Name:1-Piperidinecarboxylic acid, 4-[[[5-[3-chloro-4-(phenylmethoxy)phenyl]-3-(1,1-dimethylethyl)-6-fluoro- 7-methoxy-1-methyl-3H-pyrazolo[3,4-c]isoquinolin-8-yl]oxy]methyl]-, 1,1-dimethylethyl ester
CAS No.:838856-96-5
Molecular Formula:C40H46ClFN4O5
Molecular Weight:717.28
Hs Code.:

1-Piperidinecarboxylic acid,
4-[[[5-[3-chloro-4-(phenylmethoxy)phenyl]-3-(1,1-dimethylethyl)-6-fluoro-
7-methoxy-1-methyl-3H-pyrazolo[3,4-c]isoquinolin-8-yl]oxy]methyl]-,
1,1-dimethylethyl ester

Synonyms:

Suppliers and Price of 1-Piperidinecarboxylic acid, 4-[[[5-[3-chloro-4-(phenylmethoxy)phenyl]-3-(1,1-dimethylethyl)-6-fluoro- 7-methoxy-1-methyl-3H-pyrazolo[3,4-c]isoquinolin-8-yl]oxy]methyl]-, 1,1-dimethylethyl ester

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Chemical Property of 1-Piperidinecarboxylic acid, 4-[[[5-[3-chloro-4-(phenylmethoxy)phenyl]-3-(1,1-dimethylethyl)-6-fluoro- 7-methoxy-1-methyl-3H-pyrazolo[3,4-c]isoquinolin-8-yl]oxy]methyl]-, 1,1-dimethylethyl ester

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Technology Process of 1-Piperidinecarboxylic acid, 4-[[[5-[3-chloro-4-(phenylmethoxy)phenyl]-3-(1,1-dimethylethyl)-6-fluoro- 7-methoxy-1-methyl-3H-pyrazolo[3,4-c]isoquinolin-8-yl]oxy]methyl]-, 1,1-dimethylethyl ester

There total 15 articles about 1-Piperidinecarboxylic acid, 4-[[[5-[3-chloro-4-(phenylmethoxy)phenyl]-3-(1,1-dimethylethyl)-6-fluoro- 7-methoxy-1-methyl-3H-pyrazolo[3,4-c]isoquinolin-8-yl]oxy]methyl]-, 1,1-dimethylethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 838856-95-4
5-{3-chloro-4-[(phenylmethyl)oxy]phenyl}-3-(1,1-dimethylethyl)-6-fluoro-1-methyl-7-(methyloxy)-3H-pyrazolo[3,4-c]isoquinolin-8-ol

: 161975-39-9
tert-butyl 4-(((methylsulfonyl)oxy)methyl)piperidine-1-carboxylate

: 838856-96-5
1,1-dimethylethyl-4-({[5-{3-chloro-4-[(phenylmethyl)oxy]phenyl}-3-(1,1-dimethylethyl)-6-fluoro-1-methyl-7-(methyloxy)-3H-pyrazolo[3,4-c]isoquiolin-8-yl]oxy}methyl)piperidine-1-carboxylate

Guidance literature:: With caesium carbonate; In N,N-dimethyl-formamide; at 90 ℃; for 24h;

Reference yield:

: 838856-88-5
3-fluoro-5-hydroxy-4-methoxybenzoic acid methyl ester

: 838856-96-5
1,1-dimethylethyl-4-({[5-{3-chloro-4-[(phenylmethyl)oxy]phenyl}-3-(1,1-dimethylethyl)-6-fluoro-1-methyl-7-(methyloxy)-3H-pyrazolo[3,4-c]isoquiolin-8-yl]oxy}methyl)piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 9 steps

1.1: caesium carbonate / N,N-dimethyl-formamide / 12 h / 20 °C

2.1: lithium aluminium tetrahydride / tetrahydrofuran / 0.5 h / 0 °C

3.1: pyridine; thionyl chloride / dichloromethane / 0.08 h / 0 - 20 °C

4.1: N,N-dimethyl-formamide / 12 h / 20 °C

5.1: sodium hydride / tetrahydrofuran / 0.58 h / 0 - 20 °C

6.1: ethanol / 12 h / 75 °C

7.1: hydrogen / palladium 10% on activated carbon / ethanol / 9 h / 20 °C / 2585.81 Torr

7.2: pH 7

8.1: acetic acid / 19 h / 90 °C

8.2: 90 °C

9.1: caesium carbonate / N,N-dimethyl-formamide / 24 h / 90 °C

With pyridine; lithium aluminium tetrahydride; thionyl chloride; hydrogen; sodium hydride; caesium carbonate; acetic acid; palladium 10% on activated carbon; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 838856-91-0
5-(chloromethyl)-1-fluoro-2-(methyloxy)-3-[(phenylmethyl)oxy]benzene

: 838856-96-5
1,1-dimethylethyl-4-({[5-{3-chloro-4-[(phenylmethyl)oxy]phenyl}-3-(1,1-dimethylethyl)-6-fluoro-1-methyl-7-(methyloxy)-3H-pyrazolo[3,4-c]isoquiolin-8-yl]oxy}methyl)piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 6 steps

1.1: N,N-dimethyl-formamide / 12 h / 20 °C

2.1: sodium hydride / tetrahydrofuran / 0.58 h / 0 - 20 °C

3.1: ethanol / 12 h / 75 °C

4.1: hydrogen / palladium 10% on activated carbon / ethanol / 9 h / 20 °C / 2585.81 Torr

4.2: pH 7

5.1: acetic acid / 19 h / 90 °C

5.2: 90 °C

6.1: caesium carbonate / N,N-dimethyl-formamide / 24 h / 90 °C

With hydrogen; sodium hydride; caesium carbonate; acetic acid; palladium 10% on activated carbon; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide;