2-Chloro-4-methyl-5,6,7,8-tetrahydroquinazoline

Base Information

• Chemical Name: 2-Chloro-4-methyl-5,6,7,8-tetrahydroquinazoline
• CAS No.: 83939-60-0
• Molecular Formula: C₉H₁₁ClN₂
• Molecular Weight: 182.653
• Hs Code.: 2933990090
• DSSTox Substance ID: DTXSID90518543
• Wikidata: Q82381272
• Mol file: 83939-60-0.mol

Synonyms:2-CHLORO-4-METHYL-5,6,7,8-TETRAHYDROQUINAZOLINE;83939-60-0;SCHEMBL13523663;DTXSID90518543;MFCD12827458;AKOS006343800;BS-38481;CS-0365209

Chemical Property of 2-Chloro-4-methyl-5,6,7,8-tetrahydroquinazoline

Chemical Property:

• PSA: 25.78000
• LogP: 2.31720
• XLogP3: 2.8
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 0
• Exact Mass: 182.0610761
• Heavy Atom Count: 12
• Complexity: 163

Purity/Quality:

99% ^*data from raw suppliers

2-chloro-4-methyl-5,6,7,8-tetrahydroquinazoline ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=C2CCCCC2=NC(=N1)Cl

Technology Process of 2-Chloro-4-methyl-5,6,7,8-tetrahydroquinazoline

There total 3 articles about 2-Chloro-4-methyl-5,6,7,8-tetrahydroquinazoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

4-Methyl-5,6,7,8-tetrahydro-1H-quinazolin-2-one (88267-97-4) → 2-Chloro-4-methyl-5,6,7,8-tetrahydro-quinazoline (83939-60-0)

Guidance literature:

With trichlorophosphate; for 4h; Heating;

DOI:10.1248/cpb.31.2254

Reference yield:

2-acetylcyclohexanone (874-23-7,125117-37-5) → 2-Chloro-4-methyl-5,6,7,8-tetrahydro-quinazoline (83939-60-0)

Guidance literature:

Multi-step reaction with 3 steps

1: conc. HCl / ethanol / 4 h / Heating

2: 10percent NaOH / H₂O / 8 h / Heating

3: 52 percent / POCl₃ / 4 h / Heating

With hydrogenchloride; sodium hydroxide; trichlorophosphate; In ethanol; water;

DOI:10.1248/cpb.31.2254

Reference yield:

[2-(1-Carbamoylimino-ethyl)-cyclohex-1-enyl]-urea (344559-87-1) → 2-Chloro-4-methyl-5,6,7,8-tetrahydro-quinazoline (83939-60-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 10percent NaOH / H₂O / 8 h / Heating

2: 52 percent / POCl₃ / 4 h / Heating

With sodium hydroxide; trichlorophosphate; In water;

DOI:10.1248/cpb.31.2254

upstream raw materials:

4-Methyl-5,6,7,8-tetrahydro-1H-quinazolin-2-one

2-acetylcyclohexanone

[2-(1-Carbamoylimino-ethyl)-cyclohex-1-enyl]-urea

Downstream raw materials:

2-(4-Benzyl-piperazin-1-yl)-4-methyl-5,6,7,8-tetrahydro-quinazoline; hydrochloride

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 83939-60-0 2-chloro-4-methyl-5,6,7,8-tetrahydroquinazoline(SALTDATA: FREE)

Send

Send

Metric Ton KG G Pound L ML

Send

Send