3-(2-(4-Methyl-piperazin-1-yl)-vinyl)-pyrido(3,4-e)(1,2,4)triazine

Base Information

Chemical Name:3-(2-(4-Methyl-piperazin-1-yl)-vinyl)-pyrido(3,4-e)(1,2,4)triazine
CAS No.:121845-71-4
Molecular Formula:C13H16 N6
Molecular Weight:256.31
Hs Code.:
ChEMBL ID:CHEMBL314393
Mol file:121845-71-4.mol

Synonyms:121845-71-4;3-(2-(4-Methyl-piperazin-1-yl)-vinyl)-pyrido(3,4-e)(1,2,4)triazine;3-[2-(4-Methyl-piperazin-1-yl)-vinyl]-pyrido[3,4-e][1,2,4]triazine;CHEMBL314393;3-[(E)-2-(4-methylpiperazin-1-yl)vinyl]pyrido[3,4-e][1,2,4]triazine

Suppliers and Price of 3-(2-(4-Methyl-piperazin-1-yl)-vinyl)-pyrido(3,4-e)(1,2,4)triazine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 3-(2-(4-Methyl-piperazin-1-yl)-vinyl)-pyrido(3,4-e)(1,2,4)triazine

Chemical Property:

Vapor Pressure:1.67E-08mmHg at 25°C
Boiling Point:456°Cat760mmHg
Flash Point:229.6°C
Density:1.323g/cm³
XLogP3:-0.1
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:2
Exact Mass:256.14364454
Heavy Atom Count:19
Complexity:312

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CN1CCN(CC1)C=CC2=NC3=C(C=CN=C3)N=N2
Isomeric SMILES:CN1CCN(CC1)/C=C/C2=NC3=C(C=CN=C3)N=N2

Technology Process of 3-(2-(4-Methyl-piperazin-1-yl)-vinyl)-pyrido(3,4-e)(1,2,4)triazine

There total 8 articles about 3-(2-(4-Methyl-piperazin-1-yl)-vinyl)-pyrido(3,4-e)(1,2,4)triazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 38.0%

: 109-01-3
1-methyl-piperazine

: 121845-69-0
N,N-dimethyl-2-(pyrido<3,4-e>-1,2,4-triazin-3-yl)ethenamine

: 121845-71-4
3-<2-(4-methyl-1-piperazinyl)ethenyl>pyrido<3,4-e>-1,2,4-triazine

Guidance literature:: for 17h; Heating;
DOI:10.1021/jm00131a010

Reference yield:

: 5435-54-1
4-hydroxy-3-nitropyridine

: 121845-71-4
3-<2-(4-methyl-1-piperazinyl)ethenyl>pyrido<3,4-e>-1,2,4-triazine

Guidance literature:: Multi-step reaction with 7 steps

1: 87 percent / PCl₅, POCl₃ / 6 h / 130 - 140 °C

2: ethanol / 5 h / Heating

3: H₂ / 5percent Pd/C / aq. ethanol / 2327.2 Torr

4: HCl / ethanol / 1.) 25 deg C, 5 h, 2.) reflux, 1.5 h

5: MnO₂, 5 M NaOH / H₂O / 0.83 h / pH 6

6: 41 percent / 2 h / 90 - 100 °C

7: 38 percent / 17 h / Heating

With hydrogenchloride; manganese(IV) oxide; sodium hydroxide; phosphorus pentachloride; hydrogen; trichlorophosphate; palladium on activated charcoal; In ethanol; water;
DOI:10.1021/jm00131a010

Reference yield:

: 626-64-2,157061-69-3
pyridin-4-ol

: 121845-71-4
3-<2-(4-methyl-1-piperazinyl)ethenyl>pyrido<3,4-e>-1,2,4-triazine

Guidance literature:: Multi-step reaction with 8 steps

1: 72 percent / HNO₃, H₂SO₄, SO₃ / 1 h / Heating

2: 87 percent / PCl₅, POCl₃ / 6 h / 130 - 140 °C

3: ethanol / 5 h / Heating

4: H₂ / 5percent Pd/C / aq. ethanol / 2327.2 Torr

5: HCl / ethanol / 1.) 25 deg C, 5 h, 2.) reflux, 1.5 h

6: MnO₂, 5 M NaOH / H₂O / 0.83 h / pH 6

7: 41 percent / 2 h / 90 - 100 °C

8: 38 percent / 17 h / Heating

With hydrogenchloride; manganese(IV) oxide; sodium hydroxide; phosphorus pentachloride; sulfuric acid; sulfur trioxide; hydrogen; nitric acid; trichlorophosphate; palladium on activated charcoal; In ethanol; water;
DOI:10.1021/jm00131a010