Technology Process of Oxazole,
4,5-dihydro-4-(phenylmethyl)-2-[[tris(1-methylethyl)silyl]ethynyl]-, (4S)-
There total 3 articles about Oxazole,
4,5-dihydro-4-(phenylmethyl)-2-[[tris(1-methylethyl)silyl]ethynyl]-, (4S)- which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
palladium diacetate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; lithium tert-butoxide;
In
1,4-dioxane;
at 100 ℃;
for 16h;
optical yield given as %ee;
regioselective reaction;
Inert atmosphere;
DOI:10.1021/ol100488v
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: MeLi / tetrahydrofuran; diethyl ether / 1 h / 0 °C
1.2: 100 percent / tetrahydrofuran; diethyl ether / 1 h / -78 °C
2.1: 100 percent / PyBOP; N-methylmorpholine / dimethylformamide / 20 h / 20 °C
3.1: 338.3 mg / diethylaminosulfur trifluoride / CH2Cl2 / 0.17 h / -78 °C
With
4-methyl-morpholine; diethylamino-sulfur trifluoride; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; methyllithium;
In
tetrahydrofuran; diethyl ether; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1039/b413604g
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 100 percent / PyBOP; N-methylmorpholine / dimethylformamide / 20 h / 20 °C
2: 338.3 mg / diethylaminosulfur trifluoride / CH2Cl2 / 0.17 h / -78 °C
With
4-methyl-morpholine; diethylamino-sulfur trifluoride; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate;
In
dichloromethane; N,N-dimethyl-formamide;
DOI:10.1039/b413604g
