1-Isopropylpyrazole-5-boronic Acid

Base Information

• Chemical Name: 1-Isopropylpyrazole-5-boronic Acid
• CAS No.: 839714-33-9
• Molecular Formula: C6H11BN2O2
• Molecular Weight: 153.977
• Hs Code.: 2933199090
• Mol file: 839714-33-9.mol

Synonyms:1-Isopropylpyrazole-5-boronicAcid;2-isopropyl-2H-pyrazole-3-boronic acid;1-ISOPROPYL-1H-PYRAZOLE-5-BORONIC ACID;

Chemical Property of 1-Isopropylpyrazole-5-boronic Acid

Chemical Property:

• PSA: 58.28000
• LogP: -0.85620
• Storage Temp.: Inert atmosphere,Store in freezer, under -20°C

Purity/Quality:

97% ^*data from raw suppliers

1-Isopropylpyrazole-5-boronicacid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-Isopropylpyrazole-5-boronic Acid

There total 2 articles about 1-Isopropylpyrazole-5-boronic Acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

1-isopropyl-1H-pyrazole (18952-87-9) → [1-(propan-2-yl)-1H-pyrazol-5-yl]boronic acid (839714-33-9)

Guidance literature:

1-isopropyl-1H-pyrazole; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 2.5h;

With Triisopropyl borate; In tetrahydrofuran; hexane; at -78 - 20 ℃;

With hydrogenchloride; water; In tetrahydrofuran; hexane; pH=7;

DOI:10.1021/jm9007328

Reference yield:

boric acid tributyl ester (688-74-4) + 1-isopropyl-1H-pyrazole (18952-87-9) → [1-(propan-2-yl)-1H-pyrazol-5-yl]boronic acid (839714-33-9)

Guidance literature:

1-isopropyl-1H-pyrazole; With n-butyllithium; In tetrahydrofuran; hexane; at -78 - 0 ℃; for 1h;

boric acid tributyl ester; In tetrahydrofuran; hexane; at -78 - 20 ℃;

With water; ammonium chloride; In tetrahydrofuran; hexane;

Reference yield: 99.0%

[1-(propan-2-yl)-1H-pyrazol-5-yl]boronic acid (839714-33-9) + 2-bromo-N-tert-butyl-6-[4-(trifluoromethyl)-phenyl]pyridine-4-carboxamide → N-tert-butyl-2-(2-propan-2-ylpyrazol-3-yl)-6-[4-(trifluoromethyl)phenyl]pyridine-4-carboxamide

Guidance literature:

With palladium diacetate; sodium carbonate; triphenylphosphine; In 1,2-dimethoxyethane; at 105 ℃; for 16h; Sealed tube;

upstream raw materials:

1-isopropyl-1H-pyrazole

boric acid tributyl ester

Downstream raw materials:

1-isopropyl-5-(2-methoxy-5-nitrophenyl)-1H-pyrazole

2'-fluoro-5-(2-isopropyl-2H-pyrazol-3-yl)-4'-methyl-biphenyl-3-carboxylic acid methyl ester

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