2,6,11,15,18-Pentaazadocosanoic acid, 6,11-bis[(1,1-dimethylethoxy)carbonyl]-17-(4-hydroxyphenyl)-16,19-diox o-, 1,1-dimethylethyl ester, (17R)-

Base Information

Chemical Name:2,6,11,15,18-Pentaazadocosanoic acid, 6,11-bis[(1,1-dimethylethoxy)carbonyl]-17-(4-hydroxyphenyl)-16,19-diox o-, 1,1-dimethylethyl ester, (17R)-
CAS No.:839720-17-1
Molecular Formula:C37H63N5O9
Molecular Weight:721.935
Hs Code.:

2,6,11,15,18-Pentaazadocosanoic acid,
6,11-bis[(1,1-dimethylethoxy)carbonyl]-17-(4-hydroxyphenyl)-16,19-diox
o-, 1,1-dimethylethyl ester, (17R)-

Synonyms:

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Chemical Property of 2,6,11,15,18-Pentaazadocosanoic acid, 6,11-bis[(1,1-dimethylethoxy)carbonyl]-17-(4-hydroxyphenyl)-16,19-diox o-, 1,1-dimethylethyl ester, (17R)-

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Technology Process of 2,6,11,15,18-Pentaazadocosanoic acid, 6,11-bis[(1,1-dimethylethoxy)carbonyl]-17-(4-hydroxyphenyl)-16,19-diox o-, 1,1-dimethylethyl ester, (17R)-

There total 7 articles about 2,6,11,15,18-Pentaazadocosanoic acid, 6,11-bis[(1,1-dimethylethoxy)carbonyl]-17-(4-hydroxyphenyl)-16,19-diox o-, 1,1-dimethylethyl ester, (17R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

: 172992-43-7
pentafluorophenyl butanoate

: 839720-48-8
[4-({3-[2-amino-2-(4-hydroxy-phenyl)-acetylamino]-propyl}-tert-butoxycarbonyl-amino)-butyl]-(3-tert-butoxycarbonylamino-propyl)-carbamic acid tert-butyl ester

: 839720-17-1
(3-tert-butoxycarbonylamino-propyl)-[4-(tert-butoxycarbonyl-{3-[2-butyrylamino-2-(4-hydroxy-phenyl)-acetylamino]-propyl}-amino)-butyl]-carbamic acid tert-butyl ester

Guidance literature:: With triethylamine; In dichloromethane; at 20 ℃; for 3h;
DOI:10.1021/jm049906w

Reference yield:

: 71-44-3
Spermine

: 839720-17-1
(3-tert-butoxycarbonylamino-propyl)-[4-(tert-butoxycarbonyl-{3-[2-butyrylamino-2-(4-hydroxy-phenyl)-acetylamino]-propyl}-amino)-butyl]-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: CF₃COOEt / methanol / 0.5 h / 0 °C

1.2: methanol / 20 °C

1.3: aq. NaOH / methanol / 20 °C

2.1: 72 percent / Et₃N / CH₂Cl₂ / 3 h / 20 °C

3.1: 90 percent / 1-octanethiol; DBU / tetrahydrofuran / 2 h / 20 °C

4.1: 69 percent / Et₃N / CH₂Cl₂ / 3 h / 20 °C

With Octanethiol; ethyl trifluoroacetate,; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1021/jm049906w

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 839720-17-1
(3-tert-butoxycarbonylamino-propyl)-[4-(tert-butoxycarbonyl-{3-[2-butyrylamino-2-(4-hydroxy-phenyl)-acetylamino]-propyl}-amino)-butyl]-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: CF₃COOEt / methanol / 0.5 h / 0 °C

1.2: methanol / 20 °C

1.3: aq. NaOH / methanol / 20 °C

2.1: 72 percent / Et₃N / CH₂Cl₂ / 3 h / 20 °C

3.1: 90 percent / 1-octanethiol; DBU / tetrahydrofuran / 2 h / 20 °C

4.1: 69 percent / Et₃N / CH₂Cl₂ / 3 h / 20 °C

With Octanethiol; ethyl trifluoroacetate,; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1021/jm049906w