1-Piperidinecarboxylic acid, 4-[6,11-bis[(1,1-dimethylethoxy)carbonyl]-18,18-dimethyl-1,16-dioxo-17 -oxa-2,6,11,15-tetraazanonadec-1-yl]-4-phenyl-, 9H-fluoren-9-ylmethyl ester

Base Information

Chemical Name:1-Piperidinecarboxylic acid, 4-[6,11-bis[(1,1-dimethylethoxy)carbonyl]-18,18-dimethyl-1,16-dioxo-17 -oxa-2,6,11,15-tetraazanonadec-1-yl]-4-phenyl-, 9H-fluoren-9-ylmethyl ester
CAS No.:839720-44-4
Molecular Formula:C52H73N5O9
Molecular Weight:912.18
Hs Code.:

1-Piperidinecarboxylic acid,
4-[6,11-bis[(1,1-dimethylethoxy)carbonyl]-18,18-dimethyl-1,16-dioxo-17
-oxa-2,6,11,15-tetraazanonadec-1-yl]-4-phenyl-, 9H-fluoren-9-ylmethyl
ester

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Chemical Property of 1-Piperidinecarboxylic acid, 4-[6,11-bis[(1,1-dimethylethoxy)carbonyl]-18,18-dimethyl-1,16-dioxo-17 -oxa-2,6,11,15-tetraazanonadec-1-yl]-4-phenyl-, 9H-fluoren-9-ylmethyl ester

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Technology Process of 1-Piperidinecarboxylic acid, 4-[6,11-bis[(1,1-dimethylethoxy)carbonyl]-18,18-dimethyl-1,16-dioxo-17 -oxa-2,6,11,15-tetraazanonadec-1-yl]-4-phenyl-, 9H-fluoren-9-ylmethyl ester

There total 5 articles about 1-Piperidinecarboxylic acid, 4-[6,11-bis[(1,1-dimethylethoxy)carbonyl]-18,18-dimethyl-1,16-dioxo-17 -oxa-2,6,11,15-tetraazanonadec-1-yl]-4-phenyl-, 9H-fluoren-9-ylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 114459-62-0
tri-Boc-spermine

: 839719-84-5
pentafluorophenyl DL-1-(9H-fluoren-9-ylmethoxycarbonyl)-4-phenylpiperidine-4-carboxylate

: 839720-44-4
4-[3-(tert-butoxycarbonyl-{4-[tert-butoxycarbonyl-(3-tert-butoxycarbonylamino-propyl)-amino]-butyl}-amino)-propylcarbamoyl]-4-phenyl-piperidine-1-carboxylic acid 9H-fluoren-9-ylmethyl ester

Guidance literature:: With triethylamine; In dichloromethane; at 20 ℃; for 3h;
DOI:10.1021/jm049906w

Reference yield:

: 71-44-3
Spermine

: 839720-44-4
4-[3-(tert-butoxycarbonyl-{4-[tert-butoxycarbonyl-(3-tert-butoxycarbonylamino-propyl)-amino]-butyl}-amino)-propylcarbamoyl]-4-phenyl-piperidine-1-carboxylic acid 9H-fluoren-9-ylmethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: CF₃COOEt / methanol / 0.5 h / 0 °C

1.2: methanol / 20 °C

1.3: aq. NaOH / methanol / 20 °C

2.1: 89 percent / Et₃N / CH₂Cl₂ / 3 h / 20 °C

With ethyl trifluoroacetate,; triethylamine; In methanol; dichloromethane;
DOI:10.1021/jm049906w

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 839720-44-4
4-[3-(tert-butoxycarbonyl-{4-[tert-butoxycarbonyl-(3-tert-butoxycarbonylamino-propyl)-amino]-butyl}-amino)-propylcarbamoyl]-4-phenyl-piperidine-1-carboxylic acid 9H-fluoren-9-ylmethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: CF₃COOEt / methanol / 0.5 h / 0 °C

1.2: methanol / 20 °C

1.3: aq. NaOH / methanol / 20 °C

2.1: 89 percent / Et₃N / CH₂Cl₂ / 3 h / 20 °C

With ethyl trifluoroacetate,; triethylamine; In methanol; dichloromethane;
DOI:10.1021/jm049906w