2,6,11,15-Tetraazaheptadecanoic acid, 17-amino-6,11-bis[(1,1-dimethylethoxy)carbonyl]-17-(4-hydroxyphenyl)- 16-oxo-, 1,1-dimethylethyl ester, (17R)-

Base Information

Chemical Name:2,6,11,15-Tetraazaheptadecanoic acid, 17-amino-6,11-bis[(1,1-dimethylethoxy)carbonyl]-17-(4-hydroxyphenyl)- 16-oxo-, 1,1-dimethylethyl ester, (17R)-
CAS No.:839720-48-8
Molecular Formula:C33H57N5O8
Molecular Weight:651.844
Hs Code.:

2,6,11,15-Tetraazaheptadecanoic acid,
17-amino-6,11-bis[(1,1-dimethylethoxy)carbonyl]-17-(4-hydroxyphenyl)-
16-oxo-, 1,1-dimethylethyl ester, (17R)-

Synonyms:

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Chemical Property of 2,6,11,15-Tetraazaheptadecanoic acid, 17-amino-6,11-bis[(1,1-dimethylethoxy)carbonyl]-17-(4-hydroxyphenyl)- 16-oxo-, 1,1-dimethylethyl ester, (17R)-

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Technology Process of 2,6,11,15-Tetraazaheptadecanoic acid, 17-amino-6,11-bis[(1,1-dimethylethoxy)carbonyl]-17-(4-hydroxyphenyl)- 16-oxo-, 1,1-dimethylethyl ester, (17R)-

There total 6 articles about 2,6,11,15-Tetraazaheptadecanoic acid, 17-amino-6,11-bis[(1,1-dimethylethoxy)carbonyl]-17-(4-hydroxyphenyl)- 16-oxo-, 1,1-dimethylethyl ester, (17R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 839720-47-7
(3-tert-butoxycarbonylamino-propyl)-[4-(tert-butoxycarbonyl-{3-[2-(9H-fluoren-9-ylmethoxycarbonylamino)-2-(4-hydroxy-phenyl)-acetylamino]-propyl}-amino)-butyl]-carbamic acid tert-butyl ester

: 839720-48-8
[4-({3-[2-amino-2-(4-hydroxy-phenyl)-acetylamino]-propyl}-tert-butoxycarbonyl-amino)-butyl]-(3-tert-butoxycarbonylamino-propyl)-carbamic acid tert-butyl ester

Guidance literature:: With Octanethiol; 1,8-diazabicyclo[5.4.0]undec-7-ene; In tetrahydrofuran; at 20 ℃; for 2h;
DOI:10.1021/jm049906w

Reference yield:

: 71-44-3
Spermine

: 839720-48-8
[4-({3-[2-amino-2-(4-hydroxy-phenyl)-acetylamino]-propyl}-tert-butoxycarbonyl-amino)-butyl]-(3-tert-butoxycarbonylamino-propyl)-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: CF₃COOEt / methanol / 0.5 h / 0 °C

1.2: methanol / 20 °C

1.3: aq. NaOH / methanol / 20 °C

2.1: 72 percent / Et₃N / CH₂Cl₂ / 3 h / 20 °C

3.1: 90 percent / 1-octanethiol; DBU / tetrahydrofuran / 2 h / 20 °C

With Octanethiol; ethyl trifluoroacetate,; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1021/jm049906w

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 839720-48-8
[4-({3-[2-amino-2-(4-hydroxy-phenyl)-acetylamino]-propyl}-tert-butoxycarbonyl-amino)-butyl]-(3-tert-butoxycarbonylamino-propyl)-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: CF₃COOEt / methanol / 0.5 h / 0 °C

1.2: methanol / 20 °C

1.3: aq. NaOH / methanol / 20 °C

2.1: 72 percent / Et₃N / CH₂Cl₂ / 3 h / 20 °C

3.1: 90 percent / 1-octanethiol; DBU / tetrahydrofuran / 2 h / 20 °C

With Octanethiol; ethyl trifluoroacetate,; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1021/jm049906w