Morpholine, 3-methyl-2-phenyl-, (2R,3S)-

Base Information

• Chemical Name: Morpholine, 3-methyl-2-phenyl-, (2R,3S)-
• CAS No.: 84025-82-1
• Molecular Formula: C₁₁H₁₅NO
• Molecular Weight: 177.246
• DSSTox Substance ID: DTXSID60487434
• Wikidata: Q82329453

Synonyms:Morpholine, 3-methyl-2-phenyl-, (2R,3S)-;84025-82-1;DTXSID60487434;NS00098898

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Chemical Property of Morpholine, 3-methyl-2-phenyl-, (2R,3S)-

Chemical Property:

• Boiling Point: 285.2±25.0 °C(Predicted)
• PSA: 21.26000
• Density: 0.997±0.06 g/cm3(Predicted)
• LogP: 2.06480
• XLogP3: 1.4
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 177.115364102
• Heavy Atom Count: 13
• Complexity: 154

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CC1C(OCCN1)C2=CC=CC=C2
• Isomeric SMILES: C[C@H]1[C@H](OCCN1)C2=CC=CC=C2

Technology Process of Morpholine, 3-methyl-2-phenyl-, (2R,3S)-

There total 9 articles about Morpholine, 3-methyl-2-phenyl-, (2R,3S)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

trans-3-methyl-4-((4-nitrophenyl)sulfonyl)-2-phenylmorpholine → trans-Phenmetrazine (134-49-6,1618-50-4,13580-23-9,57919-12-7,63971-50-6,84025-82-1,21288-73-3)

Guidance literature:

With lithium hydroxide monohydrate; 1-thiopropane; In acetonitrile; at 25 ℃; for 2h;

DOI:10.1021/ja104168q

Reference yield: 45.0%

trans-Phendimetrazine (634-03-7,711-72-8,21784-30-5,27032-15-1,29493-75-2,38323-36-3) → trans-Phenmetrazine (134-49-6,1618-50-4,13580-23-9,57919-12-7,63971-50-6,84025-82-1,21288-73-3) + trans-2-Phenyl-3,4-dimethyl-5-morpholinone (5493-96-9,16251-48-2,16251-49-3,38323-42-1,38323-43-2) + 4-formyl-3-methyl-2-phenylmorpholine (89100-80-1)

Guidance literature:

With sodium periodate; ruthenium tetroxide; In tetrachloromethane; water; for 7h;

DOI:10.1002/ardp.19843170106

Reference yield:

(1RS,2SR)-2-(2-hydroxy-ethylamino)-1-phenyl-propan-1-ol (54804-28-3,110612-16-3) → trans-Phenmetrazine (134-49-6,1618-50-4,13580-23-9,57919-12-7,63971-50-6,84025-82-1,21288-73-3)

Guidance literature:

With sulfuric acid;

DOI:10.1021/jm00334a007

upstream raw materials:

(1RS,2SR)-2-(2-hydroxy-ethylamino)-1-phenyl-propan-1-ol

trans-Phendimetrazine

4-formyl-3-methyl-2-phenylmorpholine

(1R,2S)-(-)-2-Amino-1-phenyl-1-<(tert-butyldimethylsilyl)oxy>-propane

Downstream raw materials:

2-cyclohexyl-3-methyl-morpholine

3t-methyl-4-nitroso-2r-phenyl-morpholine

4-formyl-3-methyl-2-phenylmorpholine

2-cyclohexyl-3-methyl-4-nitroso-morpholine