3-Pyridazinecarboxylic acid, 6-[4-[2-(trifluoromethyl)benzoyl]-1-piperazinyl]-

Base Information

Chemical Name:3-Pyridazinecarboxylic acid, 6-[4-[2-(trifluoromethyl)benzoyl]-1-piperazinyl]-
CAS No.:840488-98-4
Molecular Formula:C17H15F3N4O3
Molecular Weight:380.326
Hs Code.:

Synonyms:6-[4-(2-trifluoromethylbenzoyl)piperazin-1-yl]pyridazine-3-carboxylic acid;

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Chemical Property of 3-Pyridazinecarboxylic acid, 6-[4-[2-(trifluoromethyl)benzoyl]-1-piperazinyl]-

Chemical Property:

PSA：86.63000
LogP:2.15890

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

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Useful:

Technology Process of 3-Pyridazinecarboxylic acid, 6-[4-[2-(trifluoromethyl)benzoyl]-1-piperazinyl]-

There total 7 articles about 3-Pyridazinecarboxylic acid, 6-[4-[2-(trifluoromethyl)benzoyl]-1-piperazinyl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 312-94-7
2-trifluoromethylbenzoyl chloride

: 840488-98-4
6-(4-(2-(trifluoromethyl)benzoyl)piperazin-1-yl)pyridazine-3-carboxylic acid

Guidance literature:: Multi-step reaction with 4 steps

1: N-ethyl-N,N-diisopropylamine / dichloromethane / 16 h / 0 - 20 °C

2: trifluoroacetic acid / dichloromethane / 4 h / 20 °C

3: tetra-(n-butyl)ammonium iodide; potassium carbonate / 1,4-dioxane / 24 h / Reflux

4: lithium hydroxide monohydrate / tetrahydrofuran; water / 6 h / 20 °C

With lithium hydroxide monohydrate; tetra-(n-butyl)ammonium iodide; potassium carbonate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water;
DOI:10.1021/jm301661h

Reference yield:

: 179534-78-2
piperazine-1-yl-(2-trifluoromethylphenyl)methanone

: 840488-98-4
6-(4-(2-(trifluoromethyl)benzoyl)piperazin-1-yl)pyridazine-3-carboxylic acid

Guidance literature:: Multi-step reaction with 2 steps

1: tetra-(n-butyl)ammonium iodide; potassium carbonate / 1,4-dioxane / 24 h / Reflux

2: lithium hydroxide monohydrate / tetrahydrofuran; water / 6 h / 20 °C

With lithium hydroxide monohydrate; tetra-(n-butyl)ammonium iodide; potassium carbonate; In tetrahydrofuran; 1,4-dioxane; water;
DOI:10.1021/jm301661h

Reference yield:

: 840491-84-1
4-(2-trifluoromethylbenzoyl)piperazine-1-carboxylic acid t-butyl ester

: 840488-98-4
6-(4-(2-(trifluoromethyl)benzoyl)piperazin-1-yl)pyridazine-3-carboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1: trifluoroacetic acid / dichloromethane / 4 h / 20 °C

2: tetra-(n-butyl)ammonium iodide; potassium carbonate / 1,4-dioxane / 24 h / Reflux

3: lithium hydroxide monohydrate / tetrahydrofuran; water / 6 h / 20 °C

With lithium hydroxide monohydrate; tetra-(n-butyl)ammonium iodide; potassium carbonate; trifluoroacetic acid; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water;
DOI:10.1021/jm301661h