Pentanedioic acid, 4-[2-bromo-5-(methoxycarbonyl)phenyl]-2-(3,4-dimethyl-3-pentenyl)-2-( methoxymethyl)-3-oxo-, 5-methyl 1-[2-(trimethylsilyl)ethyl] ester, (2R)-

Base Information

Chemical Name:Pentanedioic acid, 4-[2-bromo-5-(methoxycarbonyl)phenyl]-2-(3,4-dimethyl-3-pentenyl)-2-( methoxymethyl)-3-oxo-, 5-methyl 1-[2-(trimethylsilyl)ethyl] ester, (2R)-
CAS No.:840524-75-6
Molecular Formula:C28H41BrO8Si
Molecular Weight:613.618
Hs Code.:

Pentanedioic acid,
4-[2-bromo-5-(methoxycarbonyl)phenyl]-2-(3,4-dimethyl-3-pentenyl)-2-(
methoxymethyl)-3-oxo-, 5-methyl 1-[2-(trimethylsilyl)ethyl] ester, (2R)-

Synonyms:

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Chemical Property of Pentanedioic acid, 4-[2-bromo-5-(methoxycarbonyl)phenyl]-2-(3,4-dimethyl-3-pentenyl)-2-( methoxymethyl)-3-oxo-, 5-methyl 1-[2-(trimethylsilyl)ethyl] ester, (2R)-

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Technology Process of Pentanedioic acid, 4-[2-bromo-5-(methoxycarbonyl)phenyl]-2-(3,4-dimethyl-3-pentenyl)-2-( methoxymethyl)-3-oxo-, 5-methyl 1-[2-(trimethylsilyl)ethyl] ester, (2R)-

There total 8 articles about Pentanedioic acid, 4-[2-bromo-5-(methoxycarbonyl)phenyl]-2-(3,4-dimethyl-3-pentenyl)-2-( methoxymethyl)-3-oxo-, 5-methyl 1-[2-(trimethylsilyl)ethyl] ester, (2R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

: 4-bromo-3-methoxycarbonylmethyl-benzoic acid methyl ester

: 840524-73-4
(S)-2-fluorocarbonyl-2-methoxymethyl-5,6-dimethylhept-5-enoic acid 2-trimethylsilylethyl ester

: 840524-75-6
(R)-4-(2-bromo-5-methoxycarbonylphenyl)-2-(3,4-dimethylpent-3-enyl)-2-methoxymethyl-3-oxopentanedioic acid 5-methyl ester 1-(2-trimethylsilylethyl) ester

Guidance literature:: With n-butyllithium; 1,1,1,3,3,3-hexamethyl-disilazane; In diethyl ether; at 0 - 20 ℃;
DOI:10.1002/anie.200461327

Reference yield:

: 2916-68-9
2-(Trimethylsilyl)ethanol

: 840524-75-6
(R)-4-(2-bromo-5-methoxycarbonylphenyl)-2-(3,4-dimethylpent-3-enyl)-2-methoxymethyl-3-oxopentanedioic acid 5-methyl ester 1-(2-trimethylsilylethyl) ester

Guidance literature:: Multi-step reaction with 4 steps

1: 77 percent / 1,3-dicyclohexylcarbodiimide; DMAP / CH₂Cl₂ / 72 h / 20 °C

2: aq. KOH / methanol / 15 h / 45 °C

3: 1.08 g / cyanuric fluoride; pyridine / CH₂Cl₂ / 1 h / 0 °C

4: 63 percent / hexamethyldisilazane; n-BuLi / diethyl ether / 0 - 20 °C

With pyridine; dmap; potassium hydroxide; n-butyllithium; trifluoro-[1,3,5]triazine; dicyclohexyl-carbodiimide; 1,1,1,3,3,3-hexamethyl-disilazane; In methanol; diethyl ether; dichloromethane;
DOI:10.1002/anie.200461327

Reference yield:

: 216320-01-3
5-iodo-2,3-dimethyl-2-pentene

: 840524-75-6
(R)-4-(2-bromo-5-methoxycarbonylphenyl)-2-(3,4-dimethylpent-3-enyl)-2-methoxymethyl-3-oxopentanedioic acid 5-methyl ester 1-(2-trimethylsilylethyl) ester

Guidance literature:: Multi-step reaction with 7 steps

1: NaH / dimethylformamide / 72 h

2: 3.92 g / NaH / tetrahydrofuran / 1 h

3: porcine liver esterase; aq. phosphate buffer / dimethylsulfoxide / 168 h / 20 °C / pH 8.0

4: 77 percent / 1,3-dicyclohexylcarbodiimide; DMAP / CH₂Cl₂ / 72 h / 20 °C

5: aq. KOH / methanol / 15 h / 45 °C

6: 1.08 g / cyanuric fluoride; pyridine / CH₂Cl₂ / 1 h / 0 °C

7: 63 percent / hexamethyldisilazane; n-BuLi / diethyl ether / 0 - 20 °C

With pyridine; porcine liver esterase; dmap; potassium hydroxide; n-butyllithium; trifluoro-[1,3,5]triazine; phosphate buffer; sodium hydride; dicyclohexyl-carbodiimide; 1,1,1,3,3,3-hexamethyl-disilazane; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1002/anie.200461327