4-Methyl-N-(3-phenyl-5-isoxazolyl)-1-piperazinepropanamine

Base Information

Chemical Name:4-Methyl-N-(3-phenyl-5-isoxazolyl)-1-piperazinepropanamine
CAS No.:86684-10-8
Molecular Formula:C17H24N4O
Molecular Weight:300.3987
Hs Code.:
DSSTox Substance ID:DTXSID801007019

Synonyms:BRN 5580779;86684-10-8;4-Methyl-N-(3-phenyl-5-isoxazolyl)-1-piperazinepropanamine;1-Piperazinepropanamine, 4-methyl-N-(3-phenyl-5-isoxazolyl)-;DTXSID801007019;3-[3-methyl-4-(3-phenyl-1,2-oxazol-5-yl)piperazin-1-yl]propan-1-amine

Suppliers and Price of 4-Methyl-N-(3-phenyl-5-isoxazolyl)-1-piperazinepropanamine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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Total 0 raw suppliers

Chemical Property of 4-Methyl-N-(3-phenyl-5-isoxazolyl)-1-piperazinepropanamine

Chemical Property:

Vapor Pressure:4.04E-10mmHg at 25°C
Boiling Point:499.7°C at 760 mmHg
Flash Point:256°C
Density:1.105g/cm³
XLogP3:2.1
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:5
Exact Mass:300.19501140
Heavy Atom Count:22
Complexity:335

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1CN(CCN1C2=CC(=NO2)C3=CC=CC=C3)CCCN

Technology Process of 4-Methyl-N-(3-phenyl-5-isoxazolyl)-1-piperazinepropanamine

There total 4 articles about 4-Methyl-N-(3-phenyl-5-isoxazolyl)-1-piperazinepropanamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

: 86683-47-8
3-(4-Methyl-piperazin-1-yl)-N-(3-phenyl-isoxazol-5-yl)-propionamide

: 86684-10-8
[3-(4-Methyl-piperazin-1-yl)-propyl]-(3-phenyl-isoxazol-5-yl)-amine

Guidance literature:: With sodium bis(2-methoxyethoxy)aluminium dihydride; In benzene; for 12h; Ambient temperature;
DOI:10.1248/cpb.34.1634

Reference yield:

: 109-01-3
1-methyl-piperazine

: 86684-10-8
[3-(4-Methyl-piperazin-1-yl)-propyl]-(3-phenyl-isoxazol-5-yl)-amine

Guidance literature:: Multi-step reaction with 2 steps

1: 71 percent / ethanol / 2 h / Heating

2: 69 percent / 70percent sodium bis-(2-methoxyethoxy)aluminum hydride in toluene / benzene / 12 h / Ambient temperature

With sodium bis(2-methoxyethoxy)aluminium dihydride; In ethanol; benzene;
DOI:10.1248/cpb.34.1634

Reference yield:

: 4369-55-5
3-phenyl-isoxazol-5-ylamine

: 86684-10-8
[3-(4-Methyl-piperazin-1-yl)-propyl]-(3-phenyl-isoxazol-5-yl)-amine

Guidance literature:: Multi-step reaction with 3 steps

1: 74 percent / pyridine / CHCl₃ / 3.5 h / Ambient temperature

2: 71 percent / ethanol / 2 h / Heating

3: 69 percent / 70percent sodium bis-(2-methoxyethoxy)aluminum hydride in toluene / benzene / 12 h / Ambient temperature

With pyridine; sodium bis(2-methoxyethoxy)aluminium dihydride; In ethanol; chloroform; benzene;
DOI:10.1248/cpb.34.1634