4-(5-fluoro-1H-indol-3-yl)butanal

Base Information

Chemical Name:4-(5-fluoro-1H-indol-3-yl)butanal
CAS No.:843654-83-1
Molecular Formula:C₁₂H₁₂FNO
Molecular Weight:205.232
Hs Code.:
DSSTox Substance ID:DTXSID10474359
Wikidata:Q82304339

Synonyms:4-(5-fluoro-1H-indol-3-yl)butanal;843654-83-1;SCHEMBL4492524;DTXSID10474359;HHOVUDIWFGCCLG-UHFFFAOYSA-N

Suppliers and Price of 4-(5-fluoro-1H-indol-3-yl)butanal

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

AccelPharmtech
4-(5-fluoro-1H-indol-3-yl)butanal 97.00%
25G
$ 4010.00

AccelPharmtech
4-(5-fluoro-1H-indol-3-yl)butanal 97.00%
5G
$ 2180.00

AccelPharmtech
4-(5-fluoro-1H-indol-3-yl)butanal 97.00%
1G
$ 1940.00

Total 0 raw suppliers

Chemical Property of 4-(5-fluoro-1H-indol-3-yl)butanal

Chemical Property:

Boiling Point:381.7±32.0 °C(Predicted)
PSA：32.86000
Density:1.212±0.06 g/cm3(Predicted)
LogP:2.82860
XLogP3:2.7
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:4
Exact Mass:205.090292168
Heavy Atom Count:15
Complexity:222

Purity/Quality:: 4-(5-fluoro-1H-indol-3-yl)butanal 97.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC2=C(C=C1F)C(=CN2)CCCC=O

Technology Process of 4-(5-fluoro-1H-indol-3-yl)butanal

There total 7 articles about 4-(5-fluoro-1H-indol-3-yl)butanal which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 843652-74-4
methyl 4-(5-fluoro-1H-indol-3-yl)butanoate

: 843654-83-1
4-(5-fluoroindol-3-yl)butanal

Guidance literature:: With diisobutylaluminium hydride; In toluene; at -78 ℃; for 0.5h; Inert atmosphere;
DOI:10.1021/acs.orglett.6b02718

Reference yield:

: 5-fluoro-3-(4-hydroxybutyl)-1H-indole

: 843654-83-1
4-(5-fluoroindol-3-yl)butanal

Guidance literature:: With sulfur trioxide pyridine complex; triethylamine; In dichloromethane; dimethyl sulfoxide; at 0 ℃; Molecular sieve;
DOI:10.1039/c2cc35625b

Reference yield:

: C₁₇H₂₀FNO₄

: 843654-83-1
4-(5-fluoroindol-3-yl)butanal

Guidance literature:: Multi-step reaction with 4 steps

1: sodium hydroxide / ethanol / Reflux

2: neat (no solvent) / 220 °C

3: lithium aluminium tetrahydride / tetrahydrofuran / Reflux

4: sulfur trioxide pyridine complex; triethylamine / dichloromethane; dimethyl sulfoxide / 0 °C / Molecular sieve

With lithium aluminium tetrahydride; sulfur trioxide pyridine complex; triethylamine; sodium hydroxide; In tetrahydrofuran; ethanol; dichloromethane; dimethyl sulfoxide;
DOI:10.1039/c2cc35625b