10-Deacetylbaccatin III

Base Information

• Chemical Name: 10-Deacetylbaccatin III
• CAS No.: 92999-93-4
• Molecular Formula: C₂₉H₃₆O₁₀
• Molecular Weight: 544.599
• Mol file: 92999-93-4.mol

Synonyms:7,11-Methano-5H-cyclodeca[3,4]benz[1,2-b]oxet-5-one,12b-(acetyloxy)-12-(benzoyloxy)-1,2a,3,4,4a,6,9,10,11,12,12a,12b-dodecahydro-4,6,9,11-tetrahydroxy-4a,8,13,13-tetramethyl-,(2aR,4S,4aR,6R,9S,11S,12S,12aR,12bS)-;7,11-Methano-5H-cyclodeca[3,4]benz[1,2-b]oxet-5-one,12b-(acetyloxy)-12-(benzoyloxy)-1,2a,3,4,4a,6,9,10,11,12,12a,12b-dodecahydro-4,6,9,11-tetrahydroxy-4a,8,13,13-tetramethyl-,[2aR-(2aa,4b,4aa,6b,9a,11a,12a,12aa,12ba)]- (9CI);8-epi-10-Deacetylbaccatin III;10-Deacetylbaccatine III;

Chemical Property of 10-Deacetylbaccatin III

Chemical Property:

• Appearance/Colour: White to off-white crystalline powder
• Vapor Pressure: 0mmHg at 25°C
• Melting Point: 225ºC - 230 ºC
• Refractive Index: 1.624
• Boiling Point: 716.8 °C at 760 mmHg
• PKA: 11.50±0.70(Predicted)
• Flash Point: 233.5 °C
• PSA: 159.82000
• Density: 1.41 g/cm³
• LogP: 1.08180
• Storage Temp.: -20°C Freezer
• Solubility.: DMSO (Slightly), Methanol (Slightly)
• Water Solubility.: INSOLUBLE

Purity/Quality:

99% ^*data from raw suppliers

10-Deacetylbaccatin III ^*data from reagent suppliers

Safty Information:

• Pictogram(s): R23/24/25:
• Hazard Codes: T:Toxic
• Statements: R23/24/25:
• Safety Statements: S28A:; S36/37/39:; S38:; S45:

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 10-Deacetyl Baccatin III is an impurity of Paclitaxel (P132500) and derivatives. Paclitaxel - In House Impurity.

Technology Process of 10-Deacetylbaccatin III

There total 3 articles about 10-Deacetylbaccatin III which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ 10-desacetylbaccatin III (32981-86-5,71629-92-0,92999-93-4,115509-92-7,172018-16-5)

Guidance literature:

DOI:10.1039/C39790000102

Reference yield:

→ C29H36O10 (32981-86-5,71629-92-0,92999-93-4,115509-92-7,172018-16-5)

Guidance literature:

Taxol 1, Me.;

DOI:10.1021/ja00738a045

Reference yield:

→ C29H36O10 (32981-86-5,71629-92-0,92999-93-4,115509-92-7,172018-16-5)

Guidance literature:

Baccatin III (3), NaHCO3, H2O, CH3OH;

DOI:10.1039/C39790000102

Refernces