2-chloro-4-fluoro-5-nitrophenyl methyl carbonate

Base Information

• Chemical Name: 2-chloro-4-fluoro-5-nitrophenyl methyl carbonate
• CAS No.: 84478-89-7
• Molecular Formula: C8H5ClFNO5
• Molecular Weight: 249.583
• Mol file: 84478-89-7.mol

Synonyms:2-chloro-4-fluoro-5-nitrophenyl methyl carbonate;4-Chloro-5-methoxycarbonyloxy-2-fluoronitrobenzene;

Chemical Property of 2-chloro-4-fluoro-5-nitrophenyl methyl carbonate

Chemical Property:

• PSA: 81.35000
• LogP: 3.05570

Purity/Quality:

99% ^*data from raw suppliers

2-Chloro-4-fluoro-5-nitrophenyl methyl carbonate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-chloro-4-fluoro-5-nitrophenyl methyl carbonate

There total 3 articles about 2-chloro-4-fluoro-5-nitrophenyl methyl carbonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

2-chloro-4-fluoro-methoxycarbonyloxybenzene (84478-88-6) → 2-chloro-4-fluoro-5-nitro-methoxycarbonyloxybenzene (84478-89-7)

Guidance literature:

With sulfuric acid; nitric acid; at 0 ℃;

Reference yield:

2-chloro-4-fluorophenol (1996-41-4) → 2-chloro-4-fluoro-5-nitro-methoxycarbonyloxybenzene (84478-89-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 99 percent / aq. NaOH / 0.25 h / 5 - 10 °C

2: 82 percent / HNO₃; H₂SO₄ / 0.5 h / 30 °C

With sodium hydroxide; sulfuric acid; nitric acid; 1: Acylation / 2: Nitration;

DOI:10.1021/jm990345w

Reference yield:

→ ice-water + 2-chloro-4-fluoro-5-nitro-methoxycarbonyloxybenzene (84478-89-7)

Guidance literature:

upstream raw materials:

2-chloro-4-fluoro-methoxycarbonyloxybenzene

2-chloro-4-fluorophenol

Downstream raw materials:

3-amino-4-fluorophenyl methyl carbonate hydrochloride

N-[5-({2-[(cyclopropylcarbonyl)amino][1,2,4]triazolo-[1,5-a]pyridin-6-yl}oxy)-2-fluorophenyl]-1,3-dimethyl-1H-pyrazole-5-carboxamide

ethyl {[5-(3-{[(1,3-dimethyl-1H-pyrazol-5-yl)carbonyl]amino}-4-fluorophenoxy)pyridine-2-yl]carbamothioyl}carbamate

C₁₇H₁₄BrFN₄O₂

Refernces

• 1、 -. "METHODS AND COMPOSITIONS FOR THE TREATMENT OF MYELOPROLIFERATIVE DISEASES AND OTHER PROLIFERATIVE DISEASES". Paragraph 00251. . Retrieved 2013/03/26.
• 2、 -. "Compounds and Methods of Treatment". Page/Page column 15. . Retrieved 2008/12/08.