Benzyl (2-phenylethyl)phosphonochloridate

Base Information

Chemical Name:Benzyl (2-phenylethyl)phosphonochloridate
CAS No.:84690-31-3
Molecular Formula:C15H16ClO2P
Molecular Weight:294.71300
Hs Code.:
DSSTox Substance ID:DTXSID50553011

Synonyms:84690-31-3;Benzyl (2-phenylethyl)phosphonochloridate;DTXSID50553011

Suppliers and Price of Benzyl (2-phenylethyl)phosphonochloridate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemical Property of Benzyl (2-phenylethyl)phosphonochloridate

Chemical Property:

PSA：36.11000
LogP:4.87780
XLogP3:3.7
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:6
Exact Mass:294.0576444
Heavy Atom Count:19
Complexity:297

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1=CC=C(C=C1)CCP(=O)(OCC2=CC=CC=C2)Cl

Technology Process of Benzyl (2-phenylethyl)phosphonochloridate

There total 1 articles about Benzyl (2-phenylethyl)phosphonochloridate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 82180-49-2
(2-phenylethyl)phosphonic acid,dibenzyl ester

: 84690-31-3
O-benzyl-P-phenethyl phosphochloridate

Guidance literature:: With phosphorus pentachloride; In benzene; for 2.5h; Heating;
DOI:10.1021/jm00396a033

Reference yield:

: 84690-31-3
O-benzyl-P-phenethyl phosphochloridate

: (S)-1-[(S)-6-Benzyloxycarbonylamino-2-(hydroxy-phenethyl-phosphinoyloxy)-hexanoyl]-pyrrolidine-2-carboxylic acid

Guidance literature:: Multi-step reaction with 2 steps

1: Et₃N, DMAP / CH₂Cl₂ / 1.) 0 deg C, 15 min, 2.) room temperature, 1 h

2: H₂, Et₃N / Pd-C / methanol / 5 h

With dmap; hydrogen; triethylamine; palladium on activated charcoal; In methanol; dichloromethane;
DOI:10.1021/jm00396a033

Reference yield:

: 84690-31-3
O-benzyl-P-phenethyl phosphochloridate

: 110931-32-3
1-<(S)-2-hydroxy-1-oxo-6-<<(phenylmethoxy)carbonyl>amino>hexyl>-L-proline phenylmethyl ester

: 111496-31-2
1-<(S)-2-<<(phenylmethoxy)(2-phenethyl)phosphinyl>oxy>-1-oxo-6-<<(phenylmethoxy)carbonyl>amino>hexyl>-L-proline phenylmethyl ester

Guidance literature:: With dmap; triethylamine; In dichloromethane; Yield given; 1.) 0 deg C, 15 min, 2.) room temperature, 1 h;
DOI:10.1021/jm00396a033