(S)-6-(Hydroxymethyl)morpholin-3-one

Base Information

Chemical Name:(S)-6-(Hydroxymethyl)morpholin-3-one
CAS No.:847805-30-5
Molecular Formula:C5H9NO3
Molecular Weight:131.131
Hs Code.:
DSSTox Substance ID:DTXSID20466028
Nikkaji Number:J3.036.860F
Wikidata:Q82292397
Mol file:847805-30-5.mol

Synonyms:(S)-6-(Hydroxymethyl)morpholin-3-one;847805-30-5;(6S)-6-(hydroxymethyl)morpholin-3-one;SCHEMBL617929;DTXSID20466028;DMELBDGPDOJCTC-BYPYZUCNSA-N;XIB80530;MFCD09260720;(R)-6-Hydroxymethyl-morpholin-3-one;AKOS016844322;AS-50610;CS-0036959;P10705;EN300-2987046

Suppliers and Price of (S)-6-(Hydroxymethyl)morpholin-3-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
(S)-6-(Hydroxymethyl)morpholin-3-one
50mg
$ 220.00

Crysdot
(S)-6-(Hydroxymethyl)morpholin-3-one 95+%
1g
$ 515.00

Chemenu
(S)-6-(Hydroxymethyl)morpholin-3-one 95%
1g
$ 482.00

American Custom Chemicals Corporation
(S)-6-HYDROXYMETHYL-MORPHOLIN-3-ONE 95.00%
5MG
$ 496.94

Alichem
(S)-6-(Hydroxymethyl)morpholin-3-one
1g
$ 449.28

Alichem
(S)-6-(Hydroxymethyl)morpholin-3-one
250mg
$ 218.36

Total 15 raw suppliers

Chemical Property of (S)-6-(Hydroxymethyl)morpholin-3-one

Chemical Property:

Melting Point:144-146 °C
Boiling Point:397.1±27.0 °C(Predicted)
PKA:13.98±0.40(Predicted)
PSA：58.56000
Density:1?+-.0.06 g/cm3(Predicted)
LogP:-1.17750
Storage Temp.:Sealed in dry,Room Temperature
XLogP3:-1.4
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:1
Exact Mass:131.058243149
Heavy Atom Count:9
Complexity:115

Purity/Quality:

97% ^*data from raw suppliers

(S)-6-(Hydroxymethyl)morpholin-3-one ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1C(OCC(=O)N1)CO
Isomeric SMILES:C1[C@H](OCC(=O)N1)CO

Technology Process of (S)-6-(Hydroxymethyl)morpholin-3-one

There total 3 articles about (S)-6-(Hydroxymethyl)morpholin-3-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 1374255-92-1
(S)-6-[(trityloxy)methyl]morpholin-3-one

: 847805-30-5
(6S)-6-(hydroxymethyl)morpholin-3-one

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 0 - 20 ℃; for 4h;
DOI:10.1055/s-0031-1289677

Reference yield: 92.0%

: 847805-29-2
(-)-2-chloro-N-((S)-2,3-dihydroxypropyl)acetamide

: 847805-30-5
(6S)-6-(hydroxymethyl)morpholin-3-one

Guidance literature:: With potassium tert-butylate; In tert-Amyl alcohol; at 20 ℃; for 3h;
DOI:10.1021/ol050059g

Reference yield:

: 1374255-91-0
(S)-2-bromo-N-[2-hydroxy-3-(trityloxy)propyl]acetamide

: 847805-30-5
(6S)-6-(hydroxymethyl)morpholin-3-one

Guidance literature:: Multi-step reaction with 2 steps

1: sodium hydroxide / dichloromethane / 1.5 h / Reflux

2: trifluoroacetic acid / dichloromethane / 4 h / 0 - 20 °C

With trifluoroacetic acid; sodium hydroxide; In dichloromethane;
DOI:10.1055/s-0031-1289677