Bentamapimod

Base Information

Chemical Name:Bentamapimod
CAS No.:848344-36-5
Molecular Formula:C₂₅H₂₃N₅O₂S
Molecular Weight:457.556
Hs Code.:2934999090
European Community (EC) Number:805-471-3
UNII:TT3L4B4U0N
DSSTox Substance ID:DTXSID401005116
Nikkaji Number:J3.592.287C
Wikidata:Q27290300
NCI Thesaurus Code:C87441
ChEMBL ID:CHEMBL3545213
Mol file:848344-36-5.mol

Synonyms:AS602801;bentamapimod;PGL5001

Suppliers and Price of Bentamapimod

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
Bentamapimod
10mg
$ 290.00

TRC
Bentamapimod
5mg
$ 160.00

TRC
Bentamapimod
50mg
$ 1175.00

DC Chemicals
AS602801(Bentamapimod) >98%
1 g
$ 2100.00

CSNpharm
AS-602801
5mg
$ 65.00

Crysdot
AS602801 98+%
10mg
$ 234.00

Crysdot
AS602801 98+%
5mg
$ 146.00

ChemScene
Bentamapimod 99.52%
10mg
$ 120.00

ChemScene
Bentamapimod 99.52%
50mg
$ 250.00

ChemScene
Bentamapimod 99.52%
5mg
$ 70.00

Total 23 raw suppliers

Chemical Property of Bentamapimod

Chemical Property:

Boiling Point:666.5±65.0 °C(Predicted)
PKA:6.47±0.10(Predicted)
PSA：112.40000
Density:1.326
LogP:4.09088
Storage Temp.:2-8°C
Solubility.:insoluble in H2O; insoluble in EtOH; ≥11.45 mg/mL in DMSO
XLogP3:3.3
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:8
Rotatable Bond Count:7
Exact Mass:457.15724617
Heavy Atom Count:33
Complexity:660

Purity/Quality:

99%, ^*data from raw suppliers

Bentamapimod ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1COCCN1CC2=CC=C(C=C2)COC3=NC=CC(=N3)C(C#N)C4=NC5=CC=CC=C5S4
Recent ClinicalTrials:PGL5001 Proof of Concept Study in Inflammatory Endometriosis
Recent EU Clinical Trials:A Phase IIa study investigating the efficacy and safety of the c-Jun-N-Terminal Kinase (JNK) inhibitor PGL5001 versus placebo administered for up to 5 months with concomitant administration of depot medroxyprogesterone acetate (DMPA) for the treatment of peritoneal and/or ovarian endometriosis with an inflammatory component, prior to surgery.
Description Bentamapimod is an orally bioavailable inhibitor of Jun kinases (JNKs), with IC50 values for JNK1, JNK2, and JNK3 of 80, 90, and 230 nM, respectively. It is selective for JNKs over a panel of 25 related kinases. Bentamapimod induces regression of endometriotic lesions without suppressing estrogen action in animal models of endometriosis. It blocks proliferation and induces apoptosis of T cells in vitro and inhibits cancer stem cell survival, self-renewal, and tumor-initiating capacity in vitro and in mice.
Uses Bentamapimod is a potent and selective JNK inhibitor with therapeutic potential in MS (multiple sclerosis) and fibrosis. Studies show that Bentamapimod also reduced induced endometriosis in baboons.

Technology Process of Bentamapimod

There total 1 articles about Bentamapimod which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: