2-borono-5-methoxy-1H-Pyrrolo[3,2-b]pyridine-1-carboxylic acid 1-(1,1-dimethylethyl)ester

Base Information

Chemical Name:2-borono-5-methoxy-1H-Pyrrolo[3,2-b]pyridine-1-carboxylic acid 1-(1,1-dimethylethyl)ester
CAS No.:848357-95-9
Molecular Formula:C13H17BN2O5
Molecular Weight:292.099
Hs Code.:
Mol file:848357-95-9.mol

Synonyms:5-methoxy-1H-indole-2-boronic acid 1-carboxylic acid tert-butyl ester;5-methoxypyrrolo[3,2-b]pyridine-2-boronic acid 1-carboxylic acid tert-butyl ester;

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-borono-5-methoxy-1H-Pyrrolo[3,2-b]pyridine-1-carboxylic acid 1-(1,1-dimethylethyl)ester

Chemical Property:

PSA：93.81000
LogP:0.50790

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 2-borono-5-methoxy-1H-Pyrrolo[3,2-b]pyridine-1-carboxylic acid 1-(1,1-dimethylethyl)ester

There total 4 articles about 2-borono-5-methoxy-1H-Pyrrolo[3,2-b]pyridine-1-carboxylic acid 1-(1,1-dimethylethyl)ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 37.0%

: 357187-15-6
tert-butyl 5-methoxy-1H-pyrrolo[3,2-b]pyridine-1-carboxylate

: 5419-55-6
Triisopropyl borate

: 848357-95-9
(1-(tert-butoxycarbonyl)-5-methoxy-1H-pyrrolo[3,2-b]pyridin-2-yl)boronic acid

Guidance literature:: tert-butyl 5-methoxy-1H-pyrrolo[3,2-b]pyridine-1-carboxylate; With n-butyllithium; In tetrahydrofuran; at -78 ℃; for 1h;

Triisopropyl borate; In tetrahydrofuran; at -78 ℃; for 2h;

Reference yield: 37.0%

: 357187-15-6
tert-butyl 5-methoxy-1H-pyrrolo[3,2-b]pyridine-1-carboxylate

: 848357-95-9
(1-(tert-butoxycarbonyl)-5-methoxy-1H-pyrrolo[3,2-b]pyridin-2-yl)boronic acid

Guidance literature:: tert-butyl 5-methoxy-1H-pyrrolo[3,2-b]pyridine-1-carboxylate; With tert.-butyl lithium; In tetrahydrofuran; at -78 ℃; for 1h;

With Triisopropyl borate; In tetrahydrofuran; at -78 ℃; for 2h;

With hydrogenchloride; In water; pH=3 - 4;

Reference yield:

: 17288-40-3
5-methoxy-4-aza-1H-indole

: 848357-95-9
(1-(tert-butoxycarbonyl)-5-methoxy-1H-pyrrolo[3,2-b]pyridin-2-yl)boronic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: triethylamine; dmap / dichloromethane / 20 °C / Inert atmosphere

2.1: n-butyllithium / tetrahydrofuran / 1 h / -78 °C

2.2: 2 h / -78 °C

With dmap; n-butyllithium; triethylamine; In tetrahydrofuran; dichloromethane;