1-(4-tert-butylphenylaMino)isoquinolin-2(1H)-ylboronic acid

Base Information

Chemical Name:1-(4-tert-butylphenylaMino)isoquinolin-2(1H)-ylboronic acid
CAS No.:848841-52-1
Molecular Formula:C19H21BN2O2
Molecular Weight:320.199
Hs Code.:
Mol file:848841-52-1.mol

Synonyms:Boronic acid, [1-[[4-(1,1-dimethylethyl)phenyl]amino]-4-isoquinolinyl]-;

Suppliers and Price of 1-(4-tert-butylphenylaMino)isoquinolin-2(1H)-ylboronic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 1 raw suppliers

Chemical Property of 1-(4-tert-butylphenylaMino)isoquinolin-2(1H)-ylboronic acid

Chemical Property:

PSA：65.38000
LogP:3.02870

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 1-(4-tert-butylphenylaMino)isoquinolin-2(1H)-ylboronic acid

There total 2 articles about 1-(4-tert-butylphenylaMino)isoquinolin-2(1H)-ylboronic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 848841-51-0
(4-bromoisoquinolin-1-yl)(4-tert-butylphenyl)amine

: 848841-52-1
(4-boronoic acid isoquinolin-1-yl)-(4-tert-butylphenyl)amine

Guidance literature:: (4-bromoisoquinolin-1-yl)(4-tert-butylphenyl)amine; With n-butyllithium; In tetrahydrofuran; hexane; at -74 ℃; for 1h;

With Triisopropyl borate; In tetrahydrofuran; hexane; at -74 - 20 ℃; for 4.5h;

With water; In tetrahydrofuran; hexane; at 20 ℃;

Reference yield:

: 19493-44-8
1-chloroisoquinoline

: 848841-52-1
(4-boronoic acid isoquinolin-1-yl)-(4-tert-butylphenyl)amine

Guidance literature:: Multi-step reaction with 3 steps

1: hydrogenchloride / butan-1-ol; water / 3 h / 70 °C / Inert atmosphere

2: phenyltrimethylammonium tribromide / tetrahydrofuran / 0 - 20 °C / Inert atmosphere

3: n-butyllithium; Triisopropyl borate / tetrahydrofuran; hexane / 5.5 h / -74 °C / Inert atmosphere

With hydrogenchloride; n-butyllithium; Triisopropyl borate; phenyltrimethylammonium tribromide; In tetrahydrofuran; hexane; water; butan-1-ol;
DOI:10.1021/op0501601

Reference yield: 60.9%

: 848841-52-1
(4-boronoic acid isoquinolin-1-yl)-(4-tert-butylphenyl)amine

: 135361-30-7
7-[(trifluoromethyl)sulfonyl]oxyisoquinoline

: [4,7']bis-isoquinolinyl-1-yl-(4-tert-butylphenyl)amine

Guidance literature:: With bis-triphenylphosphine-palladium(II) chloride; potassium carbonate; In N,N-dimethyl-formamide; at 20 - 100 ℃; for 2h; Inert atmosphere;
DOI:10.1021/op0501601