4-Methoxy-3-methylbenzenesulfonyl chloride

Base Information

• Chemical Name: 4-Methoxy-3-methylbenzenesulfonyl chloride
• CAS No.: 84910-98-5
• Molecular Formula: C8H9ClO3S
• Molecular Weight: 220.677
• Hs Code.: 2909309090
• European Community (EC) Number: 833-386-1
• DSSTox Substance ID: DTXSID80579466
• Wikidata: Q82469991
• Mol file: 84910-98-5.mol

Synonyms:84910-98-5;4-methoxy-3-methylbenzenesulfonyl chloride;4-Methoxy-3-methyl-benzenesulfonyl chloride;4-methoxy-3-methylbenzene-1-sulfonyl chloride;MFCD08445775;4-methoxy-3-methylbenzene-1-sulfonylchloride;SCHEMBL739939;DTXSID80579466;JJDPJUVEBAXEDF-UHFFFAOYSA-N;6-methoxy-m-toluensulfonyl chloride;GS3076;AKOS000154220;AKOS024318849;FS-4808;4-methoxy-3-methyl benzenesulfonyl chloride;2-OXO-2-(3-PYRIDYL)ACETALDEHYDEOXIME;EN300-37290;W16402;4-methoxy-3-methyl-benzenesulfonyl chloride, AldrichCPR;F2190-0566;Z283680996

Chemical Property of 4-Methoxy-3-methylbenzenesulfonyl chloride

Chemical Property:

• PSA: 51.75000
• LogP: 3.01190
• XLogP3: 2.8
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 219.9960930
• Heavy Atom Count: 13
• Complexity: 257

Purity/Quality:

98%min ^*data from raw suppliers

4-Methoxy-3-methylbenzenesulfonylChloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=C(C=CC(=C1)S(=O)(=O)Cl)OC

Technology Process of 4-Methoxy-3-methylbenzenesulfonyl chloride

There total 2 articles about 4-Methoxy-3-methylbenzenesulfonyl chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-methylmethoxybenzene (578-58-5) → bis-(4-methoxy-3-methyl-phenyl)-sulfone (66294-56-2) + 4-methoxy-3-methylbenzene-1-sulfonyl chloride (84910-98-5)

Guidance literature:

With chlorosulphuric acid;

Reference yield:

→ 4-methoxy-3-methylbenzene-1-sulfonyl chloride (84910-98-5)

Guidance literature:

Reference yield: 92.0%

4-methoxy-3-methylbenzene-1-sulfonyl chloride (84910-98-5) + 2-chloro-6,7-dimethoxyquinazolin-4-amine (23680-84-4) → N-(2-chloro-6,7-dimethoxyquinazolin-4-yl)-4-methoxy-3-methylbenzenesulfonamide

Guidance literature:

2-chloro-6,7-dimethoxyquinazolin-4-amine; With sodium hydride; In tetrahydrofuran; N,N-dimethyl-formamide; mineral oil; at 20 ℃; for 0.5h; Inert atmosphere;

4-methoxy-3-methylbenzene-1-sulfonyl chloride; In tetrahydrofuran; N,N-dimethyl-formamide; mineral oil; at 0 - 20 ℃; for 14.1667h; Inert atmosphere;

DOI:10.1016/j.bmcl.2017.03.042

upstream raw materials:

2-methylmethoxybenzene

Downstream raw materials:

bis-(4-methoxy-3-methyl-phenyl)-sulfone

4-methoxy-3-methylbenzenethiol

(4-methoxy-3-methyl-phenyl)-(4-methoxy-phenyl)-sulfone

2-methoxy-5-(toluene-4-sulfonyl)-toluene

Refernces