1-Piperazinecarboxylic acid, 4-[5-[[(phenylMethoxy)carbonyl]aMino]-2-pyridinyl]-phenylMethyl ester

Base Information

Chemical Name:1-Piperazinecarboxylic acid, 4-[5-[[(phenylMethoxy)carbonyl]aMino]-2-pyridinyl]-phenylMethyl ester
CAS No.:849145-80-8
Molecular Formula:C25H26N4O4
Molecular Weight:446.506
Hs Code.:
Mol file:849145-80-8.mol

Synonyms:4-(5-Benzyloxycarbonylamino-pyridin-2-yl)-piperazine-1-carboxylic acid benzyl ester;

Suppliers and Price of 1-Piperazinecarboxylic acid, 4-[5-[[(phenylMethoxy)carbonyl]aMino]-2-pyridinyl]-phenylMethyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-Piperazinecarboxylic acid, 4-[5-[[(phenylMethoxy)carbonyl]aMino]-2-pyridinyl]-phenylMethyl ester

Chemical Property:

Melting Point:157 - 158 °C (H2O)
PSA：84.00000
LogP:4.36500

Purity/Quality:: 97-99% ^*data from raw suppliers

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Technology Process of 1-Piperazinecarboxylic acid, 4-[5-[[(phenylMethoxy)carbonyl]aMino]-2-pyridinyl]-phenylMethyl ester

There total 3 articles about 1-Piperazinecarboxylic acid, 4-[5-[[(phenylMethoxy)carbonyl]aMino]-2-pyridinyl]-phenylMethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.7%

: 501-53-1,94274-21-2
benzyl chloroformate

: 119285-06-2
6-(piperazin-1-yl)pyridin-3-amine

: 849145-80-8
2-(4-carbobenzyloxypiperazin-1-yl)-5-(carbobenzyloxyamino)pyridine

Guidance literature:: With sodium carbonate; In water; acetone; at 20 ℃;
DOI:10.1016/j.ejmech.2004.10.012

Reference yield:

: 4548-45-2
2-chloro-5-nitropyridine

: 849145-80-8
2-(4-carbobenzyloxypiperazin-1-yl)-5-(carbobenzyloxyamino)pyridine

Guidance literature:: Multi-step reaction with 3 steps

1: 84.6 percent / acetonitrile / 2.5 h / 20 °C

2: H₂ / Pd/C / tetrahydrofuran / 20 °C / 760 Torr

3: 86.7 percent / Na₂CO₃ / acetone; H₂O / 20 °C

With hydrogen; sodium carbonate; palladium on activated charcoal; In tetrahydrofuran; water; acetone; acetonitrile;
DOI:10.1016/j.ejmech.2004.10.012

Reference yield:

: 82205-58-1
1-(5-nitro-2-pyridinyl)piperazine

: 849145-80-8
2-(4-carbobenzyloxypiperazin-1-yl)-5-(carbobenzyloxyamino)pyridine

Guidance literature:: Multi-step reaction with 2 steps

1: H₂ / Pd/C / tetrahydrofuran / 20 °C / 760 Torr

2: 86.7 percent / Na₂CO₃ / acetone; H₂O / 20 °C

With hydrogen; sodium carbonate; palladium on activated charcoal; In tetrahydrofuran; water; acetone;
DOI:10.1016/j.ejmech.2004.10.012