Benzenehexanol, 4-hydroxy-

Base Information

• Chemical Name: Benzenehexanol, 4-hydroxy-
• CAS No.: 849675-06-5
• Molecular Formula: C12H18O2
• Molecular Weight: 194.274
• Mol file: 849675-06-5.mol

Synonyms:

Chemical Property of Benzenehexanol, 4-hydroxy-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Benzenehexanol, 4-hydroxy-

There total 8 articles about Benzenehexanol, 4-hydroxy- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

1-(4-benzyloxyphenyl)-6-hydroxyhexan-1-one → 6-(4-hydroxyphenyl)-1-hexanol (849675-06-5)

Guidance literature:

With 5%-palladium/activated carbon; hydrogen; at 40 ℃; under 3750.38 Torr;

Reference yield:

4-((E)-6-Hydroxy-hex-1-enyl)-phenol → 6-(4-hydroxyphenyl)-1-hexanol (849675-06-5)

Guidance literature:

With hydrogen; platinum(IV) oxide; In methanol; under 2585.7 Torr;

DOI:10.1021/jm960167w

Reference yield:

(4-carboxybutyl)triphenylphosphonium bromide (17814-85-6) → 6-(4-hydroxyphenyl)-1-hexanol (849675-06-5)

Guidance literature:

Multi-step reaction with 4 steps

1: 1.) NaCH₂SOCH₃ / 1.) DMSO, RT, 30 min, 2.) DMSO, RT, 1 h

2: diethyl ether; methanol

3: DIBAL-H / CH₂Cl₂ / 0.5 h / 0 °C

4: H₂ / PtO₂ / methanol / 2585.7 Torr

With hydrogen; diisobutylaluminium hydride; sodium methylsulfinylmethanide; platinum(IV) oxide; In methanol; diethyl ether; dichloromethane;

DOI:10.1021/jm960167w

upstream raw materials:

(4-carboxybutyl)triphenylphosphonium bromide

4-hydroxy-benzaldehyde

hexahydro-2H-oxepin-2-one

(4-(benzyloxy)phenyl)magnesium bromide

Downstream raw materials:

4-(6-bromohexyl)phenol

3-Cyano-3-hydroxy-4-[6-(4-hydroxy-phenyl)-hexylsulfanyl]-butyric acid methyl ester

Thioacetic acid S-[6-(4-hydroxy-phenyl)-hexyl] ester